On the interrelation of 1/f neural noise and norepinephrine system activity during motor response inhibition.
On the interrelation of 1/f neural noise and norepinephrine system activity during motor response inhibition.
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运动反应抑制过程中 1/f 神经噪声与去甲肾上腺素系统活动的相互关系
DOI：
10.1152/jn.00701.2018
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发表时间：
2019
影响因子：
2.5
通讯作者：
Ziemssen
中科院分区：
文献类型：
--
作者：
Pertermann;Mückschel;Adelhöfer;Ziemssen
一些证据表明，神经回路中噪声的程度与去甲肾上腺素(NE)系统的活动之间存在密切的相互关系，但在人类信息处理和认知控制过程中，这些方面之间的确切联系远未被理解。我们研究了47名健康参与者在反应抑制过程中的这种联系。利用高密度的脑电记录，我们通过计算这些数据的“1/f噪声”来估计神经噪声，并将这些脑电参数与瞳孔直径数据相结合，作为NE系统活动的间接指标。我们表明，当施加认知控制过程以抑制优势/自动反应时，神经噪声被减少。这些神经噪声变化被限制在theta频段，这也被证明在反应抑制和认知控制中发挥着核心作用。在中央顶叶电极位置，在Nogo刺激呈现后的前250ms内，1/f神经噪声参数与瞳孔直径数据之间有很强的正相关。在自动响应On Go试验中，没有明显的这种相关性。用标准化低分辨率脑电磁断层扫描进行的来源定位分析表明，在NOGO试验中，顶下区域在这个时间段被激活。这些数据表明，当需要认知控制过程时，在与顶下区相关的信息处理的早期阶段，去甲肾上腺素系统活动和神经噪声之间存在相互关系。这些数据首次为人类抑制控制中去甲肾上腺素系统活动与神经噪声调制之间的联系提供了直接证据。这是第一次研究表明在人类抑制控制过程中去甲肾上腺素系统活动与神经噪声或无标度神经活动的调制之间存在联系。它通过将瞳孔直径数据与脑电神经噪声分析相结合来实现这一点。
Several lines of evidence suggest that there is a close interrelation between the degree of noise in neural circuits and the activity of the norepinephrine (NE) system, yet the precise nexus between these aspects is far from being understood during human information processing and cognitive control in particular. We examine this nexus during response inhibition inn= 47 healthy participants. Using high-density EEG recordings, we estimate neural noise by calculating “1/fnoise” of those data and integrate these EEG parameters with pupil diameter data as an established indirect index of NE system activity. We show that neural noise is reduced when cognitive control processes to inhibit a prepotent/automated response are exerted. These neural noise variations were confined to the theta frequency band, which has also been shown to play a central role during response inhibition and cognitive control. There were strong positive correlations between the 1/fneural noise parameter and the pupil diameter data within the first 250 ms after the Nogo stimulus presentation at centro-parietal electrode sites. No such correlations were evident during automated responding on Go trials. Source localization analyses using standardized low-resolution brain electromagnetic tomography show that inferior parietal areas are activated in this time period in Nogo trials. The data suggest an interrelation of NE system activity and neural noise within early stages of information processing associated with inferior parietal areas when cognitive control processes are required. The data provide the first direct evidence for the nexus between NE system activity and the modulation of neural noise during inhibitory control in humans.NEW & NOTEWORTHYThis is the first study showing that there is a nexus between norepinephrine system activity and the modulation of neural noise or scale-free neural activity during inhibitory control in humans. It does so by integrating pupil diameter data with analysis of EEG neural noise.
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DOI：
10.1093/ijnp/pyy063
发表时间：
2018-10-01
期刊：
The international journal of neuropsychopharmacology
影响因子：
--
作者：
Bensmann W;Roessner V;Stock AK;Beste C
通讯作者：
Beste C
去甲肾上腺素系统及其与多成分行为的相关性
影响因子：
5.7
作者：
Mückschel;Ziemssen
通讯作者：
Ziemssen
DOI：
10.1016/j.nicl.2018.10.027
发表时间：
2018
期刊：
NeuroImage. Clinical
影响因子：
--
作者：
Bluschke A;Friedrich J;Schreiter ML;Roessner V;Beste C
通讯作者：
Beste C
影响因子：
4.6
作者：
Vahid A;Mückschel M;Neuhaus A;Stock AK;Beste C
通讯作者：
Beste C
影响因子：
5.7
作者：
Dippel, Gabriel;Mueckschel, Moritz;Beste, Christian
通讯作者：
Beste, Christian