The "Magnesium Sacrifice" Strategy Enables PMMA Bone Cement Partial Biodegradability and Osseointegration Potential.
The "Magnesium Sacrifice" Strategy Enables PMMA Bone Cement Partial Biodegradability and Osseointegration Potential.
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“牺牲镁”策略使 PMMA 骨水泥具有部分生物降解性和骨整合潜力
DOI：
10.3390/ijms19061746
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发表时间：
2018-06-12
影响因子：
5.6
通讯作者：
Li B
中科院分区：
文献类型：
--
作者：
Zhai Q;Han F;He Z;Shi C;Zhou P;Zhu C;Guo Q;Zhu X;Yang H;Li B
聚甲基丙烯酸甲酯（PMMA）基骨水泥具有优良的可注射性和力学性能，是最常用的可注射骨科材料。然而，它们的生物相容性差和过度僵硬可能导致无菌植入物松动和应力屏蔽等并发症。在这项研究中，我们旨在开发一种新型的部分可生物降解的复合骨水泥，通过在PMMA基质中加入镁（Mg）微球，称为“Mg牺牲”（MgSs）。PMMA中的MgSs对生理环境敏感，可以逐渐降解产生具有生物活性的Mg离子，同时在水泥基体内部形成相互连接的大孔结构。研究了PMMA-Mg骨水泥的力学性能、固化性能和体内体外生物相容性。有趣的是，Mg微球的掺入并没有显著影响骨水泥的机械强度。然而，骨水泥凝固时的最高温度降低。这种部分可生物降解的复合骨水泥具有良好的体外生物相容性。在体内研究中，mggs降解后，孔隙中出现了相当大的骨长入。总之，本研究的结果表明，这种部分可生物降解的PMMA-Mg复合材料可能是微创骨科手术（如椎体成形术和后凸成形术）的理想骨水泥。
Poly (methyl methacrylate) (PMMA)-based bone cements are the most commonly used injectable orthopedic materials due to their excellent injectability and mechanical properties. However, their poor biocompatibility and excessive stiffness may cause complications such as aseptic implant loosening and stress shielding. In this study, we aimed to develop a new type of partially biodegradable composite bone cement by incorporating magnesium (Mg) microspheres, known as “Mg sacrifices” (MgSs), in the PMMA matrix. Being sensitive to the physiological environment, the MgSs in PMMA could gradually degrade to produce bioactive Mg ions and, meanwhile, result in an interconnected macroporous structure within the cement matrix. The mechanical properties, solidification, and biocompatibility, both in vitro and in vivo, of PMMA–Mg bone cement were characterized. Interestingly, the incorporation of Mg microspheres did not markedly affect the mechanical strength of bone cement. However, the maximum temperature upon setting of bone cement decreased. This partially biodegradable composite bone cement showed good biocompatibility in vitro. In the in vivo study, considerable bony ingrowth occurred in the pores upon MgS degradation. Together, the findings from this study indicate that such partially biodegradable PMMA–Mg composite may be ideal bone cement for minimally invasive orthopedic surgeries such as vertebroplasty and kyphoplasty.
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影响因子：
0.7
作者：
Cimatti B;Engel EE;Nogueira-Barbosa MH;Frighetto PD;Volpon JB
通讯作者：
Volpon JB
DOI：
10.1002/jbm.b.31731
发表时间：
2010-11-01
影响因子：
3.4
作者：
Fukuda, C.;Goto, K.;Nakamura, T.
通讯作者：
Nakamura, T.
影响因子：
3.7
作者：
Li T;Weng X;Bian Y;Zhou L;Cui F;Qiu Z
通讯作者：
Qiu Z
DOI：
10.1002/jbm.b.31044
发表时间：
2008-08-01
影响因子：
3.4
作者：
Boger, Andreas;Bohner, Marc;Schneider, Erich
通讯作者：
Schneider, Erich
DOI：
10.1002/jbm.820260803
发表时间：
1992-08-01
期刊：
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH
影响因子：
--
作者：
COOK, SD;THOMAS, KA;KAY, JF
通讯作者：
KAY, JF