The Relationship Between Depression Symptoms and Adolescent Neural Response During Reward Anticipation and Outcome Depends on Developmental Timing: Evidence From a Longitudinal Study.
The Relationship Between Depression Symptoms and Adolescent Neural Response During Reward Anticipation and Outcome Depends on Developmental Timing: Evidence From a Longitudinal Study.
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DOI：
10.1016/j.bpsc.2020.11.001
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发表时间：
2021-05
期刊：
影响因子：
--
通讯作者：
Barch DM
中科院分区：
文献类型：
--
作者：
Luking KR;Gilbert K;Kelly D;Kappenman ES;Hajcak G;Luby JL;Barch DM
在青年抑郁症中观察到迟钝的神经奖励反应（RR）。然而，目前尚不清楚是否抑郁症的症状经历了早期的发展与青少年RR超越目前的症状，并进一步，这种关系是否与RR不同的奖励处理的两个关键组成部分：预期和结果。在一项针对早期抑郁症的前瞻性纵向研究中，儿童和照顾者从学前班开始完成了半年一次的诊断评估。在青春期后期，平均年龄= 16.49岁（SD = 0.94），青年（N=100）的神经生理反应信号可能赢和输，这些结果进行了评估。纵向评估的维度抑郁和外化症状（通常与抑郁症共病，也与RR相关）（学龄前3-5.11岁，学龄6-9.11岁，青春期早期10-14.11岁，电流）被用作事件相关电位的同时预测指标，该事件相关电位指示预期线索加工（线索-P3）和结果加工（奖励积极性-RewP/反馈消极性-FN，反馈-P3）。迟钝的动机注意信号可能赢的线索（线索P3）是专门预测的青春期早期抑郁症状。钝的初始反应赢（RewP）和损失（FN）的结果是专门预测学龄前抑郁症状。钝的动机显着性的输赢结果（反馈P3）预测的累积抑郁症，不特定于任何发展阶段。虽然迟钝的预期和结果RR是抑郁症的一个常见的发现，具体的赤字相关的动机注意线索和最初的结果处理可能映射到这些症状的发展过程。
Blunted neural reward responsiveness (RR) is observed in youth depression. However, it is unclear whether symptoms of depression experienced early in development relate to adolescent RR beyond current symptoms and further, whether such relationships with RR differ during two key components of reward processing: anticipation and outcome. Within a prospective longitudinal study oversampled for early depression, children and caregivers completed semi-annual diagnostic assessments beginning in preschool. In later adolescence, mean age = 16.49 years (SD = 0.94), youths’ (N=100) neurophysiological responses to cues signaling likely win and loss and these outcomes were assessed. Longitudinally assessed dimensional depression and externalizing symptoms (often co-morbid with depression and also associated with RR) experienced at different developmental periods (preschool 3–5.11 years, school-age 6–9.11 years, early-adolescent 10–14.11 years, current) were used as simultaneous predictors of event-related potentials indexing anticipatory cue processing (cue-P3) and outcome processing (Reward Positivity-RewP/Feedback Negativity-FN, feedback-P3). Blunted motivated attention to cues signaling likely win (cue-P3) was specifically predicted by early-adolescent depression symptoms. Blunted initial response to win (RewP) and loss (FN) outcomes was specifically predicted by preschool depression symptoms. Blunted motivational salience of win and loss outcomes (feedback-P3) was predicted by cumulative depression, not specific to any developmental stage. Although blunted anticipation and outcome RR is a common finding in depression, specific deficits related to motivated attention to cues and initial outcome processing may map onto the developmental course of these symptoms.
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影响因子：
19.9
作者：
Luking KR;Pagliaccio D;Luby JL;Barch DM
通讯作者：
Barch DM
DOI：
10.1038/npp.2010.164
发表时间：
2011-01
期刊：
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
影响因子：
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作者：
通讯作者：
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影响因子：
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作者：
Luby, Joan L.;Si, Xuemei;Belden, Andy C.;Tandon, Mini;Spitznagel, Ed
通讯作者：
Spitznagel, Ed
影响因子：
3.7
作者：
Hajcak, Greg;Moser, Jason S.;Simons, Robert F.
通讯作者：
Simons, Robert F.
影响因子：
3
作者：
Iacono, WG;Malone, SM;McGue, M
通讯作者：
McGue, M