Lifetime prevalence of malignant and benign tumours in companion dogs: Cross-sectional analysis of Dog Aging Project baseline survey.
Lifetime prevalence of malignant and benign tumours in companion dogs: Cross-sectional analysis of Dog Aging Project baseline survey.
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DOI：
10.1111/vco.12839
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发表时间：
2022-12
影响因子：
2.1
通讯作者：
Ruple, Audrey
中科院分区：
文献类型：
--
作者：
Schwartz, Stephen M.;Urfer, Silvan R.;White, Michelle;Megquier, Kate;Shrager, Sandi;Ruple, Audrey
虽然癌症被广泛认为是犬发病率和死亡率的主要因素，但其在伴侣犬中的频率很少被描述。我们分析了截至2020年12月31日参加犬龄项目的27541只生活伴侣犬的主人基线调查的横断面数据，以估计恶性和良性肿瘤的终生患病率以及几个潜在相关特征。调查问题引出了“癌症或肿瘤”病史的信息，包括器官部位和组织学类型。狗主人报告了819例恶性肿瘤（56%位于皮肤、肌肉或其他软组织）和404例良性肿瘤（69%位于皮肤、肌肉或其他软组织）。恶性肿瘤的终生患病率（29.7/1 000只狗）大约是良性肿瘤终生患病率（14.7/1 000只狗）的两倍。在调查完成时，恶性和良性肿瘤的终生患病率随着犬龄的增加而增加。在混合犬与纯种犬中，年龄校正的恶性肿瘤终生患病率（患病率比（PR）= 0.93 [95%置信区间（CI）0.82，1.07]或良性肿瘤（PR = 1.10，95% CI 0.91，1.34））无统计学上可辨别的差异。恶性肿瘤的终生患病率随着犬的体型等级的增加而增加;与玩具犬和小型犬相比，中型犬、标准犬、大型犬和巨型犬的年龄调整PR（95%CI）为1.65（1.28，2.11）、2.92（2.35，3.64）、3.67（2.92，4.62）和2.99（1.23，4.02）。对于良性肿瘤，观察到与犬大小类别相关的相似但不太明显的模式。正在进行的前瞻性数据收集将允许未来对犬肿瘤发病率的风险因素进行研究。
Although cancer is widely regarded as a major contributor to canine morbidity and mortality, its frequency in companion dogs has only infrequently been characterised. We analysed cross-sectional data from the baseline survey of owners of 27 541 living companion dogs enrolled in the Dog Aging Project as of 31 December 2020 to estimate the lifetime prevalence of malignant and benign tumours and several potentially-associated characteristics. Survey questions elicited information on history of ‘cancer or tumors’ including organ site and histologic type. Owners reported 819 malignant tumours (56% sited in the skin, muscle or other soft tissue) and 404 benign tumours (69% sited in the skin, muscle or other soft tissue). The lifetime prevalence of malignant tumours (29.7/1000 dogs) was approximately double the lifetime prevalence of benign tumours (14.7/1000 dogs). Lifetime prevalence of both malignant and benign tumours increased with dog age at survey completion. There were no statistically discernable differences in age-adjusted lifetime prevalence of malignant (prevalence ratio (PR) = 0.93 [95% confidence interval (CI) 0.82, 1.07] or benign tumours (PR = 1.10, 95% CI 0.91, 1.34) in mixed vs. purebred dogs. The lifetime prevalence of malignant tumours increased with increasing dog size class; compared to toy and small dogs, the age-adjusted PRs (95% CIs) for medium, standard, large, and giant dogs were 1.65 (1.28, 2.11), 2.92 (2.35, 3.64), 3.67 (2.92, 4.62) and 2.99 (1.23, 4.02), respectively. Similar though less pronounced patterns in relation to dog size class were observed for benign tumours. Ongoing prospective data collection will permit future studies on risk factors for canine tumour incidence.
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影响因子：
1.8
作者：
Ito D;Frantz AM;Modiano JF
通讯作者：
Modiano JF
影响因子：
--
作者：
Urfer, Silvan R;Kaeberlein, Matt;Creevy, Kate E
通讯作者：
Creevy, Kate E
影响因子：
--
作者：
Edmunds GL;Smalley MJ;Beck S;Errington RJ;Gould S;Winter H;Brodbelt DC;O'Neill DG
通讯作者：
O'Neill DG
影响因子：
1.6
作者：
Dobson, JM;Samuel, S;Wood, JLN
通讯作者：
Wood, JLN
影响因子：
16.8
作者：
Caulin AF;Maley CC
通讯作者：
Maley CC