Polysaccharide-Enriched Fraction from Amillariella Mellea Fruiting Body Improves Insulin Resistance
Polysaccharide-Enriched Fraction from Amillariella Mellea Fruiting Body Improves Insulin Resistance
复制标题
来自蜜环子实体的富含多糖的部分可改善胰岛素抵抗
DOI：
10.3390/molecules24010046
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发表时间：
2018-12
期刊：
影响因子：
4.6
通讯作者：
Yuying Fan
中科院分区：
文献类型：
--
作者：
Siwen Yang;Yuhan Meng;Jingmin Yan;Na Wang;Zhujun Xue;Hang Zhang;Yuying Fan
尽管食用菌Amillariella mellea具有多种生物活性，但其对糖尿病的作用仍不清楚。多糖是其主要的生物活性成分。为了破坏细胞壁以获得更多的多糖，我们用氢氧化钠溶液提取蜜环菌的子实体。碱提物(AAMP)是一种富含多糖组分。以高脂饮食(HFD)和地塞米松(DEX)联合治疗的2型糖尿病大鼠为模型，观察AAMP的降血糖作用。结果表明，口服大剂量AAMP可显著降低空腹血糖，改善糖耐量和胰岛素抵抗。AAMP还能增加LPL水平和两种关键脂肪酶ATGL和HSL的表达，从而降低血清甘油三酯。此外，AAMP特异性抑制SREBP-1c的表达，导致AAMP显著抑制肝脏中的脂质积聚。提示AAMP对HFD/DEX诱导的胰岛素抵抗的改善作用与其调节脂代谢有关。提示AAMP有可能成为一种治疗糖尿病的新型天然药物或保健食品。
Despite the edible fungus Amillariella mellea possessing a variety of biological activities, its effects on diabetes are still unclear. Polysaccharides are the main bioactive ingredients. In order to destroy the cell wall to obtain more polysaccharides, we used NaOH solution to extract Amillariella mellea fruiting bodies. The alkali extraction (AAMP) was identified as a polysaccharide-enriched fraction. Using type 2 diabetic rats induced by co-treatment of a high fat diet (HFD) and dexamethasone (DEX), we evaluated the hypoglycemic effects of AAMP. The results showed that oral administration of a high dose of AAMP markedly lowered fasting blood glucose, improving glucose intolerance and insulin resistance. AAMP also enhanced the level of LPL and the expressions of two critical lipases ATGL and HSL, leading to a decrease of serum triglyceride. In addition, AAMP specifically suppressed the expression of SREBP-1c, resulting in AAMP observably inhibiting lipid accumulation in the liver. These findings demonstrated that the improvement of AAMP on HFD/DEX-induced insulin resistance was correlated with its regulation of lipid metabolism. Our results indicated that AAMP could be a novel natural drug or health food used for the treatment of diabetes.
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影响因子：
29
作者：
Farese RV Jr;Zechner R;Newgard CB;Walther TC
通讯作者：
Walther TC
影响因子：
4.1
作者：
V. Ooi;Fang Liu
通讯作者：
V. Ooi;Fang Liu
DOI：
10.1039/jr9540000171
发表时间：
1954-01-01
期刊：
JOURNAL OF THE CHEMICAL SOCIETY
影响因子：
--
作者：
BARKER, SA;BOURNE, EJ;WHIFFEN, DH
通讯作者：
WHIFFEN, DH
影响因子：
--
作者：
Shen Ye-shou
通讯作者：
Shen Ye-shou
影响因子：
64.8
作者：
Kahn, Steven E.;Hull, Rebecca L.;Utzschneider, Kristina M.
通讯作者：
Utzschneider, Kristina M.