Morphology and microstructure of subcortical structures at birth: A large-scale Asian neonatal neuroimaging study
Morphology and microstructure of subcortical structures at birth: A large-scale Asian neonatal neuroimaging study
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出生时皮质下结构的形态和微观结构：一项大规模的亚洲新生儿神经影像学研究
DOI：
10.1016/j.neuroimage.2012.09.032
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发表时间：
2013
期刊：
影响因子：
5.7
通讯作者：
M. Meaney
中科院分区：
文献类型：
--
作者：
A. Qiu;M. Fortier;Jordan Bai Bingren;Xuejie Zhang;Y. Chong;K. Kwek;S. Saw;K. Godfrey;P. Gluckman;M. Meaney
本文采用t2加权磁共振成像（MRI）和弥散张量成像（DTI）对亚洲新生儿大规模队列中丘脑和基底神经节的生长模式和性别二态性进行了研究。我们的研究观察到，在出生后早期（孕龄36 - 43周），丘脑和基底节区（尾状核、壳核、苍白球和内囊前肢）的强劲生长超过了整个大脑的生长。此外，这两种结构的微观结构是一体化的，在生命的最初几周，分数各向异性（FA）的增加和轴向和径向水扩散系数的降低反映了这两种结构的微观结构。性别二态性只在整个大脑发育和左丘脑体积中观察到，而在出生时基底神经节和丘脑的其他体积或DTI测量中没有观察到。尽管总脑容量的性别二态性模式在出生时就存在，并在出生后的大脑发育中持续存在，但基底节区和丘脑的性别二态性与大脑发育后期发现的不同，这表明男性和女性在出生后出现了出生后大脑发育的区域差异模式。
This paper presents the growth pattern and sexual dimorphism of the thalamus and basal ganglia in a large-scale Asian neonatal cohort using both T2-weighted magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI). Our study observed a robust growth of the thalamus and basal ganglia (caudate, putamen, globus pallidus, and anterior limb of internal capsule) beyond the overall brain growth in the early postnatal period (36–43weeks of the gestational age). Additionally, the microstructure of the two structures was integrated as reflected by an increase in fractional anisotropy (FA) and a decrease in axial and radial water diffusivities in the first few weeks of life. Sexual dimorphism was only observed in the whole brain growth and the left thalamic volume but not in the other volumes or DTI measures of the basal ganglia and thalamus at birth. Even though the pattern of sexual dimorphism in the total brain volume is present at birth and persists throughout postnatal brain development, sexual dimorphisms of the basal ganglia and thalamus differ from those found in later stages of brain development, indicating that regionally distinct patterns of postnatal brain development between males and females arise after birth.
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DOI：
10.1016/j.jaac.2010.02.012
发表时间：
2010-06-01
影响因子：
13.3
作者：
Qiu, Anqi;Adler, Marcy;Mostofsky, Stewart H.
通讯作者：
Mostofsky, Stewart H.
DOI：
10.1176/appi.ajp.2008.08030426
发表时间：
2009-01
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Qiu A;Crocetti D;Adler M;Mahone EM;Denckla MB;Miller MI;Mostofsky SH
通讯作者：
Mostofsky SH
影响因子：
3.7
作者：
McKinstry, RC;Mathur, A;Neil, JJ
通讯作者：
Neil, JJ
影响因子：
3.7
作者：
Ball, William S.;Byars, Anna Weber;Levitt, Jennifer
通讯作者：
Levitt, Jennifer
DOI：
10.1176/appi.ajp.2009.09030398
发表时间：
2010-04
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Ivanov I;Bansal R;Hao X;Zhu H;Kellendonk C;Miller L;Sanchez-Pena J;Miller AM;Chakravarty MM;Klahr K;Durkin K;Greenhill LL;Peterson BS
通讯作者：
Peterson BS