Alcohol and smoking as risk factors in an epidemiology study of patients with chronic pancreatitis.
Alcohol and smoking as risk factors in an epidemiology study of patients with chronic pancreatitis.
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DOI：
10.1016/j.cgh.2010.10.015
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发表时间：
2011-03
影响因子：
12.6
通讯作者：
Sherman, Stuart
中科院分区：
文献类型：
--
作者：
Cote, Gregory A.;Yadav, Dhiraj;Slivka, Adam;Hawes, Robert H.;Anderson, Michelle A.;Burton, Frank R.;Brand, Randall E.;Banks, Peter A.;Lewis, Michele D.;Disario, James A.;Gardner, Timothy B.;Gelrud, Andres;Amann, Stephen T.;Baillie, John;Money, Mary E.;O'Connell, Michael;Whitcomb, David C.;Sherman, Stuart
60%–90% 的患者罹患慢性胰腺炎 (CP) 与酒精有关，但美国的比例尚不清楚。我们调查了美国三级转诊中心与酒精相关的脑瘫的发生频率。我们研究了 2000 年至 2006 年在 20 个美国转诊中心参加北美胰腺炎研究 2 的 CP 患者 (n=539) 和对照组 (n=695) 的数据。 CP 由影像学或组织学分析中的明确证据定义。受试者和医生各自完成了一份详细的研究问卷。根据医生指定的诊断，患者被分配到以下病因组：酒精（有/没有其他诊断）、非酒精（酒精以外的任何 CP 病因）或特发性（未确定病因）。患者在病因组中的分布为：酒精（44.5%）、非酒精（26.9%）和特发性（28.6%）。医生将酒精视为男性的病因更为常见（男性为 59.4%，女性为 28.1%），但女性中非酒精病因（男性为 18%，女性为 36.7%）和特发性病因（男性为 22.6%，女性为 35.2%）更常见（所有比较中 P<0.01）。非酒精病因同样分为阻塞性病因、遗传性病因和其他病因。与对照组相比，特发性CP患者更有可能曾经吸烟（58.6% vs 49.7%，P<0.05）或有慢性肾病或肾衰竭病史（5.2% vs 1.2%，P<0.01）。在多变量分析中，吸烟（曾经吸烟、当前吸烟和吸烟量）与特发性 CP 独立相关。美国三级转诊中心与酒精相关的脑瘫发生率低于预期。特发性脑瘫和非酒精病因代表了一个很大的亚组，特别是在女性中。吸烟是特发性脑瘫的独立危险因素。
Alcohol has been implicated in the development of chronic pancreatitis (CP) in 60%–90% patients, although percentages in the United States are not known. We investigated the frequency of alcohol-related CP at tertiary U.S. referral centers. We studied data from patients with CP (n=539) and controls (n=695) enrolled in the North American Pancreatitis Study-2 from 2000 to 2006 at 20 U.S. referral centers. CP was defined by definitive evidence in imaging or histologic analyses. Subjects and physicians each completed a detailed study questionnaire. Using physician-assigned diagnoses, patients were assigned to the following etiology groups: alcohol (with/without other diagnoses), non-alcohol (any etiology of CP from other than alcohol), or idiopathic (no etiology identified). The distribution of patients among etiology groups were: alcohol (44.5%), non-alcohol (26.9%), and idiopathic (28.6%). Physicians identified alcohol as the etiology more frequently in men (59.4% in men vs 28.1% in women), but non-alcohol (18% in men vs 36.7% in women) and idiopathic etiologies (22.6% in men vs 35.2% in women) more often in women (P<0.01 for all comparisons). Non-alcohol etiologies were equally divided among obstructive, genetic, and other causes. Compared with controls, patients with idiopathic CP were more likely to have ever smoked (58.6% vs 49.7%, P<0.05) or have a history of chronic renal disease or failure (5.2% vs 1.2%, P<0.01). In multivariate analyses, smoking (ever, current, and amount) was independently associated with idiopathic CP. The frequency of alcohol-related CP at tertiary U.S. referral centers is lower than expected. Idiopathic CP and non-alcohol etiologies represent a large subgroup, particularly among women. Smoking is an independent risk factor for idiopathic CP.
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影响因子：
3.6
作者：
Lankisch, PG;Assmus, C;Lowenfels, AB
通讯作者：
Lowenfels, AB
影响因子：
4.5
作者：
Frulloni, L.;Gabbrielli, A.;Cavallini, G.
通讯作者：
Cavallini, G.
DOI：
10.1111/j.1440-1746.2004.03426.x
发表时间：
2004-09-01
影响因子：
4.1
作者：
Garg, PK;Tandon, RK
通讯作者：
Tandon, RK
影响因子：
2.9
作者：
Imoto, M;DiMagno, EP
通讯作者：
DiMagno, EP
影响因子：
2.9
作者：
Lin, Y;Tamakoshi, A;Ohno, Y
通讯作者：
Ohno, Y