Anti-gluten immune response following Toxoplasma gondii infection in mice.
Anti-gluten immune response following Toxoplasma gondii infection in mice.
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DOI：
10.1371/journal.pone.0050991
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Yolken RH
中科院分区：
文献类型：
--
作者：
Severance EG;Kannan G;Gressitt KL;Xiao J;Alaedini A;Pletnikov MV;Yolken RH
谷蛋白敏感性可能影响精神分裂症、双相情感障碍或自闭症患者的发病机制。暴露于弓形虫是已知的精神分裂症发展的危险因素，可能是通过寄生虫对大脑和行为的直接病理影响。小麦面筋抗体和T.最近发现精神分裂症患者体内存在弓形虫感染，这表明弓形虫感染是通过一种协调的胃肠道途径。弓形虫和麸质可能会产生免疫反应。在这里，我们在小鼠模型中评估了这些感染性和食物性抗原之间的联系。BALB/c小鼠接受标准的基于小麦的啮齿动物食物，感染T.通过腹腔内、经口和产前暴露方法。与未感染对照组相比，所有感染小鼠和慢性感染母鼠的后代中抗谷蛋白IgG水平均显著增加（重复测量ANOVA，双尾t检验，所有p≤0.00001）。补体系统的激活伴随着这种免疫应答（p≤0.002-0.00001）。经口感染的雌性小鼠的抗谷蛋白IgG水平高于雄性小鼠（p≤0.009），表明T.刚地氏菌引起的胃肠道感染以性别依赖的方式导致显著的抗谷蛋白免疫应答。这些发现支持了精神分裂症的两个危险因素，T。弓形虫感染和对饮食麸质的敏感性可能与产生免疫激活有关，免疫激活正成为越来越被认识到的精神疾病的病理学。
Gluten sensitivity may affect disease pathogenesis in a subset of individuals who have schizophrenia, bipolar disorder or autism. Exposure to Toxoplasma gondii is a known risk factor for the development of schizophrenia, presumably through a direct pathological effect of the parasite on brain and behavior. A co-association of antibodies to wheat gluten and to T. gondii in individuals with schizophrenia was recently uncovered, suggesting a coordinated gastrointestinal means by which T. gondii and dietary gluten might generate an immune response. Here, we evaluated the connection between these infectious- and food-based antigens in mouse models. BALB/c mice receiving a standard wheat-based rodent chow were infected with T. gondii via intraperitoneal, peroral and prenatal exposure methods. Significant increases in the levels of anti-gluten IgG were documented in all infected mice and in offspring from chronically infected dams compared to uninfected controls (repetitive measures ANOVAs, two-tailed t-tests, all p≤0.00001). Activation of the complement system accompanied this immune response (p≤0.002–0.00001). Perorally-infected females showed higher levels of anti-gluten IgG than males (p≤0.009) indicating that T. gondii-generated gastrointestinal infection led to a significant anti-gluten immune response in a sex-dependent manner. These findings support a gastrointestinal basis by which two risk factors for schizophrenia, T. gondii infection and sensitivity to dietary gluten, might be connected to produce the immune activation that is becoming an increasingly recognized pathology of psychiatric disorders.
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影响因子：
17.7
作者：
Karlsson, Hakan;Blomstrom, Asa;Dalman, Christina
通讯作者：
Dalman, Christina
影响因子：
5.4
作者：
Dickerson, Faith;Stallings, Cassie;Yolken, Robert
通讯作者：
Yolken, Robert
影响因子：
6.9
作者：
Drude, Solveig;Geissler, Annett;Kiank-Nussbaum, Cornelia
通讯作者：
Kiank-Nussbaum, Cornelia
影响因子：
2.8
作者：
Liesenfeld, O
通讯作者：
Liesenfeld, O
DOI：
10.1016/0167-5699(91)90009-i
发表时间：
1991-09-01
期刊：
IMMUNOLOGY TODAY
影响因子：
--
作者：
FRANK, MM;FRIES, LF
通讯作者：
FRIES, LF