Diabetes and risk of Parkinson's disease.
Diabetes and risk of Parkinson's disease.
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DOI：
10.2337/dc10-1922
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发表时间：
2011-04
期刊：
影响因子：
16.2
通讯作者：
Chen H
中科院分区：
文献类型：
--
作者：
Xu Q;Park Y;Huang X;Hollenbeck A;Blair A;Schatzkin A;Chen H
研究美国老年人中糖尿病与帕金森病（PD）未来风险之间的关系。一项前瞻性研究，在美国国立卫生研究院-美国退休人员协会饮食与健康研究的288，662名参与者中，对1995年和1996年自我报告的糖尿病与1995年后诊断的PD的关系进行了研究。多变量比值比（OR）和95%CI来自logistic回归模型。共有1，565名1995年后诊断为PD的参与者被纳入分析。校正潜在混杂因素后，糖尿病患者的PD风险比非糖尿病患者高出约40%（OR = 1.41 [95%CI 1.20-1.66]）。进一步分析显示，风险升高主要限于基线调查时糖尿病超过10年的个体（1.75 [1.36-2.25]）。在1995年至1999年诊断为PD的参与者和2000年后诊断为PD的参与者中均观察到与糖尿病的相关性。此外，在排除中风、心脏病、癌症或健康状况较差或一般的参与者后，以及在按年龄、性别、吸烟状况和咖啡消费量进行的亚组分析中，也获得了类似的结果。这项大型研究表明，糖尿病与未来更高的PD风险相关，这种关联的性质需要进一步研究。
To investigate the relationship between diabetes and future risk of Parkinson’s disease (PD) among older U.S. adults. A prospective study of self-reported diabetes in 1995 and 1996 in relation to PD diagnosed after 1995 among 288,662 participants of the National Institutes of Health-AARP Diet and Health Study. Multivariate odds ratio (OR) and 95% CI were derived from logistic regression models. A total of 1,565 participants with PD diagnosed after 1995 were included in the analysis. After adjustment for potential confounders, PD risk was ∼40% higher (OR = 1.41 [95% CI 1.20–1.66]) among diabetic patients than among participants without diabetes. Further analysis showed that the risk elevation was largely limited to individuals who had diabetes for more than 10 years at the time of baseline survey (1.75 [1.36–2.25]). The association with diabetes was seen for both participants with PD diagnosed between 1995 and 1999 and participants with PD diagnosed after 2000. In addition, similar results were obtained after excluding participants with stroke, heart disease, cancers, or poor or fair health status and in subgroup analyses by age, sex, smoking status, and coffee consumption. This large study showed that diabetes was associated with a higher future risk of PD and the nature of this association warrants further investigation.
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影响因子：
16.2
作者：
Hu, Gang;Jousilahti, Pekka;Tuomilehto, Jaakko
通讯作者：
Tuomilehto, Jaakko
影响因子：
4.1
作者：
D'Amelio, Marco;Ragonese, Paolo;Savettieri, Giovanni
通讯作者：
Savettieri, Giovanni
影响因子：
16.2
作者：
Cowie, Catherine C.;Engelgau, Michael M.;Gregg, Edward W.
通讯作者：
Gregg, Edward W.
影响因子：
4.4
作者：
Miyake, Yoshihiro;Tanaka, Keiko;Nagai, Masaki
通讯作者：
Nagai, Masaki
影响因子：
16.2
作者：
Becker C;Brobert GP;Johansson S;Jick SS;Meier CR
通讯作者：
Meier CR