Mediterranean Diet Maintained Platelet Count within a Healthy Range and Decreased Thrombocytopenia-Related Mortality Risk: A Randomized Controlled Trial.
Mediterranean Diet Maintained Platelet Count within a Healthy Range and Decreased Thrombocytopenia-Related Mortality Risk: A Randomized Controlled Trial.
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DOI：
10.3390/nu13020559
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发表时间：
2021-02-08
期刊：
影响因子：
5.9
通讯作者：
Estruch R
中科院分区：
文献类型：
--
作者：
Hernáez Á;Lassale C;Castro-Barquero S;Ros E;Tresserra-Rimbau A;Castañer O;Pintó X;Vázquez-Ruiz Z;Sorlí JV;Salas-Salvadó J;Lapetra J;Gómez-Gracia E;Alonso-Gómez ÁM;Fiol M;Serra-Majem L;Sacanella E;Razquin C;Corella D;Guasch-Ferré M;Cofán M;Estruch R
There is little information on the dietary modulation of thrombosis-related risk factors such as platelet count. We aimed to assess the effects of Mediterranean diet (MedDiet) on platelet count and related outcomes in an older population at high cardiovascular risk. In participants of the PREDIMED (PREvención con DIeta MEDiterránea) study, we assessed whether an intervention with a MedDiet enriched with extra-virgin olive oil or nuts, relative to a low-fat control diet, modulated platelet count (n = 4189), the risk of developing thrombocytosis and thrombocytopenia (n = 3086), and the association between these alterations and all-cause mortality (median follow-up time: 3.0 years). Although platelet count increased over time (+0.98·109 units/L·year [95% confidence interval: 0.12; 1.84]), MedDiet interventions moderated this increase, particularly in individuals with near-high baseline count (both MedDiets combined: −3.20·109 units/L·year [−5.81; −0.59]). Thrombocytopenia incidence was lower in the MedDiet interventions (incidence rates: 2.23% in control diet, 0.91% in MedDiets combined; hazard ratio: 0.44 [0.23; 0.83]). Finally, thrombocytopenia was associated with a higher risk of all-cause mortality (hazard ratio: 4.71 [2.69; 8.24]), but this relationship was attenuated in those allocated to MedDiet (p-interaction = 0.018). In brief, MedDiet maintained platelet counts within a healthy range and attenuated platelet-related mortality in older adults at high cardiovascular risk.
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影响因子：
3.7
作者：
Casas R;Sacanella E;Urpí-Sardà M;Chiva-Blanch G;Ros E;Martínez-González MA;Covas MI;Rosa Ma Lamuela-Raventos;Salas-Salvadó J;Fiol M;Arós F;Estruch R
通讯作者：
Estruch R
影响因子：
6.3
作者：
Chiva-Blanch, Gemma;Sala-Vila, Aleix;Badimon, Lina
通讯作者：
Badimon, Lina
影响因子：
6.3
作者：
Pignatelli, Pasquale;Pastori, Daniele;Violi, Francesco
通讯作者：
Violi, Francesco
影响因子：
7.1
作者：
Ambring, A;Johansson, M;Friberg, P
通讯作者：
Friberg, P
影响因子：
4.1
作者：
Song, Pil Sang;Ahn, Kye Taek;Seong, In-Whan
通讯作者：
Seong, In-Whan