SARS-CoV-2 Omicron (B.1.1.529) Infection of Wild White-Tailed Deer in New York City.
SARS-CoV-2 Omicron (B.1.1.529) Infection of Wild White-Tailed Deer in New York City.
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DOI：
10.3390/v14122770
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发表时间：
2022-12-12
期刊：
影响因子：
--
通讯作者：
Kuchipudi SV
中科院分区：
文献类型：
--
作者：
Vandegrift KJ;Yon M;Surendran Nair M;Gontu A;Ramasamy S;Amirthalingam S;Neerukonda S;Nissly RH;Chothe SK;Jakka P;LaBella L;Levine N;Rodriguez S;Chen C;Sheersh Boorla V;Stuber T;Boulanger JR;Kotschwar N;Aucoin SG;Simon R;Toal KL;Olsen RJ;Davis JJ;Bold D;Gaudreault NN;Dinali Perera K;Kim Y;Chang KO;Maranas CD;Richt JA;Musser JM;Hudson PJ;Kapur V;Kuchipudi SV
越来越多的证据表明，SARS-CoV-2从人类传播到许多家养、伴侣和野生动物物种。研究表明，人类已经感染了白尾鹿，并且已经发生了鹿与鹿之间的传播，这表明鹿可能是野生动物的宿主和新型SARS-CoV-2变体的来源。我们检验了假设，即奥密克隆变异体是积极和无症状地感染自由放养的鹿的纽约市。2021年12月至2022年2月期间，纽约斯塔顿岛的155只鹿被麻醉，并检查是否有明显异常和疾病。采集成对的鼻咽拭子和血液样本，并分析SARS-CoV-2 RNA和抗体的存在。在135份血清样本中，有19份（14.1%）表明接触过SARS-CoV-2，11份对野生型B.1谱系反应最强烈。在71个拭子中，8个对SARS-CoV-2 RNA呈阳性（4个Omicron和4个Delta）。其中两只动物有活动性感染和强大的中和抗体，揭示了鹿再感染或早期血清转化的证据。令人担忧的变异体继续在美国鹿群中传播，并可能再次感染美国鹿群，并在野外建立地方病传播周期：这需要协调一致的“一个健康”应对措施，以主动监测、识别和减少令人担忧的变异体，以免它们重新传播给人类。
There is mounting evidence of SARS-CoV-2 spillover from humans into many domestic, companion, and wild animal species. Research indicates that humans have infected white-tailed deer, and that deer-to-deer transmission has occurred, indicating that deer could be a wildlife reservoir and a source of novel SARS-CoV-2 variants. We examined the hypothesis that the Omicron variant is actively and asymptomatically infecting the free-ranging deer of New York City. Between December 2021 and February 2022, 155 deer on Staten Island, New York, were anesthetized and examined for gross abnormalities and illnesses. Paired nasopharyngeal swabs and blood samples were collected and analyzed for the presence of SARS-CoV-2 RNA and antibodies. Of 135 serum samples, 19 (14.1%) indicated SARS-CoV-2 exposure, and 11 reacted most strongly to the wild-type B.1 lineage. Of the 71 swabs, 8 were positive for SARS-CoV-2 RNA (4 Omicron and 4 Delta). Two of the animals had active infections and robust neutralizing antibodies, revealing evidence of reinfection or early seroconversion in deer. Variants of concern continue to circulate among and may reinfect US deer populations, and establish enzootic transmission cycles in the wild: this warrants a coordinated One Health response, to proactively surveil, identify, and curtail variants of concern before they can spill back into humans.
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影响因子：
4.3
作者：
Hobbs EC;Reid TJ
通讯作者：
Reid TJ
DOI：
10.1016/j.ajpath.2021.03.004
发表时间：
2021-06
期刊：
The American journal of pathology
影响因子：
--
作者：
Long SW;Olsen RJ;Christensen PA;Subedi S;Olson R;Davis JJ;Saavedra MO;Yerramilli P;Pruitt L;Reppond K;Shyer MN;Cambric J;Finkelstein IJ;Gollihar J;Musser JM
通讯作者：
Musser JM
DOI：
10.1073/pnas.2114828118
发表时间：
2021-11-23
影响因子：
11.1
作者：
Chandler JC;Bevins SN;Ellis JW;Linder TJ;Tell RM;Jenkins-Moore M;Root JJ;Lenoch JB;Robbe-Austerman S;DeLiberto TJ;Gidlewski T;Kim Torchetti M;Shriner SA
通讯作者：
Shriner SA
影响因子：
3.2
作者：
Francisco R;Hernandez SM;Mead DG;Adcock KG;Burke SC;Nemeth NM;Yabsley MJ
通讯作者：
Yabsley MJ
影响因子：
64.8
作者：
Hale VL;Dennis PM;McBride DS;Nolting JM;Madden C;Huey D;Ehrlich M;Grieser J;Winston J;Lombardi D;Gibson S;Saif L;Killian ML;Lantz K;Tell RM;Torchetti M;Robbe-Austerman S;Nelson MI;Faith SA;Bowman AS
通讯作者：
Bowman AS