Effect of Probiotics on Glycemic Control: A Systematic Review and Meta-Analysis of Randomized, Controlled Trials.
Effect of Probiotics on Glycemic Control: A Systematic Review and Meta-Analysis of Randomized, Controlled Trials.
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益生菌对血糖控制的影响：随机对照试验的系统回顾和荟萃分析
DOI：
10.1371/journal.pone.0132121
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Chen H
中科院分区：
文献类型：
--
作者：
Ruan Y;Sun J;He J;Chen F;Chen R;Chen H
背景：先前的临床试验表明，益生菌消费可能会改善血糖控制，然而，血糖控制的随机试验结果并不一致。目的对益生菌对血糖控制作用的随机对照试验进行系统评价和荟萃分析。数据来源PubMed、Embase、科克伦图书馆和Clinicaltrial.gov，截至2014年10月。数据提取和综合两名独立的评审员提取相关数据并评估研究质量和偏倚风险。使用随机效应模型合并数据，并表示为平均差异（MD）和95% CI。评估（Cochran Q-统计）和定量（12）异质性。结果纳入17个随机对照试验，其中17个试验比较空腹血糖（n = 1105）、11个试验比较空腹血浆胰岛素（n = 788）、8个试验比较稳态模型评价胰岛素抵抗（n = 635）。与安慰剂相比，益生菌的摄入显著降低了空腹血糖（MD = -0.31 mmol/L; 95% CI 0.56，0.06; p = 0.02），空腹血浆胰岛素（MD = -1.29 μU/mL; 95% CI-2.17，-0.41; p = 0.004）和HOMA-IR（MD = 0.48; 95% CI-0.83，-0.13; p = 0.007）。结论益生菌的消费可以适度改善血糖控制。通过补充益生菌来改善肠道菌群可能是临床上预防和控制高血糖的一种方法。
Background Previous clinical trials indicate that probiotic consumption may improve blood glucose control, however, results from randomized trials on glycemic control have been inconsistent. Objective To investigate the effects of probiotics on glycemic control in a systematic review and meta-analysis of randomized controlled trials. Data Sources PubMed, Embase, Cochrane Library, and Clinicaltrial.gov through October 2014. Data Extraction and Synthesis Two independent reviewers extracted relevant data and assessed study quality and risk of bias. Data were pooled using a random-effects model and expressed as mean differences (MD) with 95% CI. Heterogeneity was assessed (Cochran Q-statistic) and quantified (I 2). Results Seventeen randomized controlled trials were included, in which 17 fasting blood glucose (n = 1105), 11 fasting plasma insulin (n = 788), 8 homeostasis model assessment of insulin resistance (n = 635) comparisons were reported. Probiotic consumption, compared with placebo, significantly reduced fasting glucose (MD = -0.31 mmol/L; 95% CI 0.56, 0.06; p = 0.02), fasting plasma insulin (MD = -1.29 μU/mL; 95% CI -2.17, -0.41; p = 0.004), and HOMA-IR (MD = 0.48; 95% CI -0.83, -0.13; p = 0.007). Conclusions Probiotic consumption may improve glycemic control modestly. Modification of gut microbiota by probiotic supplementation may be a method for preventing and control hyperglycemia in clinical practice.
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影响因子：
3.1
作者：
Burcelin, Remy;Luche, Elodie;Amar, Jacques
通讯作者：
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影响因子：
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影响因子：
4.5
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影响因子：
3.7
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通讯作者：
Jakobsen M