Linking external stimuli with internal drives: A role for the ventral hippocampus.

Linking external stimuli with internal drives: A role for the ventral hippocampus.
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DOI:
10.1016/j.conb.2022.102590
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发表时间:
2022-10
影响因子:
5.7
通讯作者:
--
中科院分区:
医学2区
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--
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腹侧海马体(VHPC)一直被认为是“情绪”的海马体。在过去的几年里,vHPC的复杂性已经暴露出来,突显了协调一系列积极和消极动机行为的细胞类型、输入和输出的多样性。在这里,我们回顾了最近的工作,即vCA1如何参与将外部刺激与内部动机驱动状态相关联的网络,以促进适应性行为反应的选择。我们提出了一个vHPC功能模型,强调它在内外线索的整合和转换中的作用,以指导面对多个潜在结果时的行为选择。
The ventral hippocampus (vHPC) has long been thought of as the “emotional” hippocampus. Over the past several years, the complexity of vHPC has come to light, highlighting the diversity of cell types, inputs, and outputs that coordinate a constellation of positively and negatively motivated behaviors. Here, we review recent work on how vCA1 contributes to a network that associates external stimuli with internal motivational drive states to promote the selection of adaptive behavioral responses. We propose a model of vHPC function that emphasizes its role in the integration and transformation of internal and external cues to guide behavioral selection when faced with multiple potential outcomes.
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