Resting-state functional connectivity of anterior and posterior hippocampus in posttraumatic stress disorder.
Resting-state functional connectivity of anterior and posterior hippocampus in posttraumatic stress disorder.
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DOI：
10.1016/j.jpsychires.2017.06.003
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发表时间：
2017-11
影响因子：
4.8
通讯作者：
Neria Y
中科院分区：
文献类型：
--
作者：
Lazarov A;Zhu X;Suarez-Jimenez B;Rutherford BR;Neria Y
创伤后应激障碍（PTSD）与包括海马在内的显著性（SN）和默认模式（DMN）网络内的几个脑区的静息态功能连接（rs-FC）改变有关。然而，大多数rs-FC研究并没有主要集中在海马，也没有认识到其结构的异质性，尽管有明确的证据表明，后海马和前海马连接之间的分离。在这里，我们研究了前海马和后海马的rs-FC与SN（杏仁核，杏仁核，背侧前扣带皮层/前辅助运动区）和DMN（腹内侧前额叶皮层，后扣带皮层，楔前叶）中的关键区域先前涉及PTSD，使用基于种子的方法。从48名PTSD患者和34名创伤暴露的健康参与者（TEHC）中获得静息状态磁共振图像。结果表明，当检查海马作为一个整体时，没有组间差异。然而，检查前海马和后海马显示PTSD患者前后连接分化丢失。与TEHC组相比，PTSD组的后海马-楔前叶通路的负连接也较低。最后，由于前海马和后海马连接的差异也与年龄有关，我们进行了二次分析，探讨两组中年龄与后海马和前海马连接之间的关系。结果表明，在PTSD患者中，年龄的增加具有使后海马-楔前叶和后海马-后扣带皮层连接正常化的作用，而对照组没有这种作用。这些发现强调了PTSD连接研究需要考虑海马的子部分，并考虑与年龄相关的连接差异。
Posttraumatic stress disorder (PTSD) has been associated with altered resting-state functional connectivity (rs-FC) of several brain regions within the salience (SN) and default-mode (DMN) networks, including the hippocampus. However, most rs-FC studies have not focused primarily on the hippocampus, nor have they appreciated its structural heterogeneity, despite clear evidence for a dissociation between posterior and anterior hippocampal connectivity. Here, we examine rs-FC of anterior and posterior hippocampus with key regions in the SN (amygdala, insula, and dorsal anterior cingulate cortex/pre-supplementary motor area) and DMN (ventromedial prefrontal cortex, posterior cingulate cortex, and precuneus) previously implicated in PTSD, using a seed-based approach. Resting-state magnetic resonance images were obtained from 48 PTSD patients and 34 trauma-exposed healthy participants (TEHC). Results indicated no group differences when examining the hippocampus as a whole. However, examining the anterior and posterior hippocampus revealed a loss of anterior to posterior connectivity differentiation in PTSD patients. The PTSD group also demonstrated lower negative connectivity of the posterior hippocampus-precuneus pathway compared with the TEHC group. Finally, as differences in anterior and posterior hippocampus connectivity have been also related to age, we performed a secondary analysis exploring the association between age and posterior-and anterior-hippocampus connectivity in both groups. Results showed that among PTSD patients, increased age had the effect of normalizing posterior hippocampus-precuneus and hippocampus-posterior cingulate cortex connectivity, whereas no such effect was noted for the control group. These findings highlight the need for PTSD connectivity research to consider sub-parts of the hippocampus and to account for age-related connectivity differences.
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影响因子：
2
作者：
Blum S;Habeck C;Steffener J;Razlighi Q;Stern Y
通讯作者：
Stern Y
影响因子：
16.2
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Fanselow, Michael S.;Dong, Hong-Wei
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Dong, Hong-Wei
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Shin, Lisa M.
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Geuze, Elbert
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作者：
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Marrelec, Guillaume