Structural atrophy of the right superior frontal gyrus in adolescents with severe irritability.
Structural atrophy of the right superior frontal gyrus in adolescents with severe irritability.
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DOI：
10.1002/hbm.25571
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发表时间：
2021-10-01
影响因子：
4.8
通讯作者：
Hwang S
中科院分区：
文献类型：
--
作者：
Seok JW;Bajaj S;Soltis-Vaughan B;Lerdahl A;Garvey W;Bohn A;Edwards R;Kratochvil CJ;Blair J;Hwang S
严重的易怒在患有精神疾病的青少年中很常见，并导致跨领域（学术，社会和家庭）的显著功能障碍。既往在儿科人群中进行的结构MRI研究表明，额-纹状体-颞区的皮质厚度（CT）和灰质体积（GMV）畸变与易激惹相关。然而，结构变化与应激性之间的相关性在各个指标的方向是不一致的。因此，我们的目标是通过基于体素的形态测量和基于表面的形态测量在具有严重易怒水平的青少年中同时实施CT，GMV和局部旋转指数（LGI）的综合评估来解决这个问题。使用T1加权MRI序列扫描108名青少年（46名严重易怒青年和62名健康青年，平均年龄= 14.08岁，标准差= 2.36）。使用情感反应指数测量易怒的严重程度。与健康青年相比，重度应激青年右侧上级额上回（SFG）的CT、GMV和LGI降低，且SFG的这些指标与应激性呈负相关。我们的研究结果表明，SFG的结构缺陷，可能与其在抑制控制中的作用有关，可能是易怒的神经生物学的关键。与健康青年相比，右侧上级额上回（SFG）的CT、GMV和LGI降低，且SFG的这些指标与易怒性呈负相关。我们的研究结果表明，SFG的结构缺陷，可能与其在抑制控制中的作用有关，可能是易怒的神经生物学的关键。
Severe irritability is common in youths with psychiatric disorders and results in significant dysfunction across domains (academic, social, and familial). Prior structural MRI studies in the pediatric population demonstrated that aberrations of cortical thickness (CT) and gray matter volume (GMV) in the fronto‐striatal‐temporal regions which have been associated with irritability. However, the directions of the correlations between structural alteration and irritability in the individual indices were not consistent. Thus, we aim to address this by implementing comprehensive assessments of CT, GMV, and local gyrification index (LGI) simultaneously in youths with severe levels of irritability by voxel‐based morphometry and surface‐based morphometry. One hundred and eight adolescents (46 youths with severe irritability and 62 healthy youths, average age = 14.08 years, standard deviation = 2.36) were scanned with a T1‐weighted MRI sequence. The severity of irritability was measured using the affective reactivity index. In youths with severe irritability, there was decreased CT, GMV, and LGI in the right superior frontal gyrus (SFG) compared to healthy youths, and negative correlations between these indices of the SFG and irritability. Our findings suggest that structural deficits in the SFG, potentially related to its role in inhibitory control, may be critical for the neurobiology of irritability. There was decreased CT, GMV, and LGI in the right superior frontal gyrus (SFG) compared to healthy youths, and negative correlations between these indices of the SFG and irritability. Our findings suggest that structural deficits in the SFG, potentially related to its role in inhibitory control, may be critical for the neurobiology of irritability.
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影响因子：
5.7
作者：
Fishburn FA;Hlutkowsky CO;Bemis LM;Huppert TJ;Wakschlag LS;Perlman SB
通讯作者：
Perlman SB
影响因子：
6.9
作者：
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作者：
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通讯作者：
Satterthwaite, Theodore D.
影响因子：
5.7
作者：
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通讯作者：
Sereno, MI
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2.9
作者：
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