Genetics and neurobiology of eating disorders.
Genetics and neurobiology of eating disorders.
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DOI：
10.1038/s41593-022-01071-z
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发表时间：
2022-05
影响因子：
25
通讯作者：
Breen, Gerome
中科院分区：
文献类型：
--
作者：
Bulik, Cynthia M.;Coleman, Jonathan R., I;Hardaway, J. Andrew;Breithaupt, Lauren;Watson, Hunna J.;Bryant, Camron D.;Breen, Gerome
进食障碍（神经性厌食症、神经性贪食症和暴食症）是一类复杂的疾病，其特征是体重和食欲失调，伴有独特的行为和心理特征。由于全基因组关联研究（GWAS）、神经影像学和动物模型方面的全球合作，我们对它们的遗传学和神经生物学的理解正在不断发展。然而，到目前为止，这些方法并行地推进了该领域，串扰不足。这篇综述涵盖了这些关键领域的重叠进展，并鼓励更大程度地整合假设和发现，以创建一个更统一的饮食失调科学。我们强调正在进行的和未来的工作，旨在确定牵连的生物学途径，这将通知分期模型的基础上，生物学以及有针对性的预防和定制的干预和激发兴趣，在开发药物，针对核心生物学的疾病，我们目前有几个有效的药物治疗。
Eating disorders (anorexia nervosa, bulimia nervosa, and binge-eating disorder) are a heterogeneous class of complex illnesses marked by weight and appetite dysregulation coupled with distinctive behavioral and psychological features. Our understanding of their genetics and neurobiology is evolving thanks to global cooperation on genome-wide association studies (GWAS), neuroimaging, and animal models. Until now, however, these approaches have advanced the field in parallel, with inadequate crosstalk. This review covers overlapping advances in these key domains and encourages greater integration of hypotheses and findings to create a more unified science of eating disorders. We highlight ongoing and future work designed to identify implicated biological pathways that will inform staging models based on biology as well as targeted prevention and tailored intervention and galvanize interest in developing pharmacologic agents that target the core biology of the illnesses for which we currently have few effective pharmacotherapeutics.
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DOI：
10.1002/wdev.375
发表时间：
2020-09
期刊：
Wiley interdisciplinary reviews. Developmental biology
影响因子：
--
作者：
Co M;Anderson AG;Konopka G
通讯作者：
Konopka G
影响因子：
25
作者：
Breen G;Li Q;Roth BL;O'Donnell P;Didriksen M;Dolmetsch R;O'Reilly PF;Gaspar HA;Manji H;Huebel C;Kelsoe JR;Malhotra D;Bertolino A;Posthuma D;Sklar P;Kapur S;Sullivan PF;Collier DA;Edenberg HJ
通讯作者：
Edenberg HJ
影响因子：
11.3
作者：
Broft A;Slifstein M;Osborne J;Kothari P;Morim S;Shingleton R;Kenney L;Vallabhajosula S;Attia E;Martinez D;Timothy Walsh B
通讯作者：
Timothy Walsh B
影响因子：
4.4
作者：
Breton, Jonathan;Legrand, Romain;Fetissov, Serguei O.
通讯作者：
Fetissov, Serguei O.
影响因子：
2.5
作者：
Corwin, Rebecca L. W.;Babbs, R. Keith
通讯作者：
Babbs, R. Keith