(Dis)Trust your gut: the gut microbiome in age-related inflammation, health, and disease.
(Dis)Trust your gut: the gut microbiome in age-related inflammation, health, and disease.
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DOI：
10.1186/s40168-017-0296-0
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发表时间：
2017-07-14
期刊：
影响因子：
15.5
通讯作者：
Buford TW
中科院分区：
文献类型：
--
作者：
Buford TW
慢性炎症是衰老最一致的生物学特征之一。然而，炎症持续低度增加的确切病因仍不清楚。最近的证据表明，肠道微生物群可能在年龄相关性炎症中发挥关键作用。事实上，几项研究表明，老年人肠道微生物区系的组成发生了变化，早期证据表明，这种生态失调与几种关键的循环炎症分析物的存在有关。本文综述了有关年龄相关性炎症的知识，并讨论了与肠道生物失调的潜在关系可能导致未来新的治疗策略。“疾病模式是人类对其整个环境(物理、生物和社会)的反应的一种表现；因此，这种反应是由任何影响人类自身或其环境的事物决定的。”--雷内·杜布斯，1961
Chronic inflammation represents one of the most consistent biologic features of aging. However, the precise etiology of persistent low-grade increases in inflammation remains unclear. Recent evidence suggests that the gut microbiome may play a key role in age-related inflammation. Indeed, several studies have indicated that older adults display an altered composition of the gut microbiota, and early evidence indicates that this dysbiosis is associated with the presence of several key circulating inflammatory analytes. The present review summarizes knowledge on age-related inflammation and discusses how potential relationships with gut dysbiosis may lead to novel treatment strategies in the future. “The pattern of disease is an expression of the response of man to his total environment (physical, biological, and social); this response is, therefore, determined by anything that affects man himself or his environment.” – Rene Dubos, 1961
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De Vos W
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