Experience dependent plasticity of higher visual cortical areas in the mouse.
Experience dependent plasticity of higher visual cortical areas in the mouse.
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DOI：
10.1093/cercor/bhad203
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发表时间：
2023-07-24
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影响因子：
--
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--
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视觉皮层的经验依赖性可塑性是研究学习记忆机制的重要范式。尽管如此，涉及操纵视觉体验的研究在很大程度上仅限于不同物种的初级视觉皮层V1。本文研究了单眼剥夺（MD）对小鼠视觉皮层V1区双眼区（V1 b）、腹侧流区（LM）和背侧流区（AL和PM）神经元的眼优势（OD）和方向选择性的影响。我们采用双光子钙成像记录神经元的反应，在年轻的成年小鼠前MD，MD后立即，和双目恢复。MD后OD变化最大LM和AL和PM最小; LM和AL中，这些变化主要通过减少剥夺眼反应介导，V1 b和LM通过增加非剥夺眼反应介导。仅V1的OD指数在2周内恢复至MD前水平。MD引起的方向选择性的V1 b和LM的剥夺眼反应的减少。我们的研究结果表明，在较高的视觉领域的OD的变化是不均匀的继承V1。
Experience dependent plasticity in the visual cortex is a key paradigm for the study of mechanisms underpinning learning and memory. Despite this, studies involving manipulating visual experience have largely been limited to the primary visual cortex, V1, across various species. Here we investigated the effects of monocular deprivation (MD) on the ocular dominance (OD) and orientation selectivity of neurons in four visual cortical areas in the mouse: the binocular zone of V1 (V1b), the putative “ventral stream” area LM and the putative “dorsal stream” areas AL and PM. We employed two-photon calcium imaging to record neuronal responses in young adult mice before MD, immediately after MD, and following binocular recovery. OD shifts following MD were greatest in LM and smallest in AL and PM; in LM and AL, these shifts were mediated primarily through a reduction of deprived-eye responses, in V1b and LM through an increase in response through the non-deprived eye. The OD index recovered to pre-MD levels within 2 weeks in V1 only. MD caused a reduction in orientation selectivity of deprived-eye responses in V1b and LM only. Our results suggest that changes in OD in higher visual areas are not uniformly inherited from V1.
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影响因子：
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作者：
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