Environmental Conditions Affect Exhalation of H3N2 Seasonal and Variant Influenza Viruses and Respiratory Droplet Transmission in Ferrets.
Environmental Conditions Affect Exhalation of H3N2 Seasonal and Variant Influenza Viruses and Respiratory Droplet Transmission in Ferrets.
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环境条件会影响H3N2季节性和变体流感病毒的呼气以及雪貂中的呼吸液滴传播。
DOI：
10.1371/journal.pone.0125874
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Maines TR
中科院分区：
文献类型：
--
作者：
Gustin KM;Belser JA;Veguilla V;Zeng H;Katz JM;Tumpey TM;Maines TR
温带气候下流感病毒感染的季节性以及温度和湿度等环境条件在流感病毒通过空气传播中的作用尚不清楚。使用雪貂居住在四个不同的环境条件下，我们评估了呼吸道飞沫传播的两种流感病毒（季节性H3 N2病毒和H3 N2变异病毒，猪的病原病毒，人夏季感染），同时其特征的气溶胶脱落配置文件的感染动物。对不同温度和湿度条件以及两种病毒进行了比较，以确定H3 N2变异病毒是否表现出可能导致夏季感染的增强能力。我们在这里报告说，虽然在雪貂鼻洗液和呼出气溶胶样品中发现H3 N2变异病毒的水平增加，与季节性H3 N2病毒相比，在任何环境设置下都没有观察到呼吸道飞沫传播增强。然而，总体环境条件显示出调节流感病毒通过空气传播的频率。在23°C/30%RH下传播最频繁，而感染雪貂呼出的气溶胶中的传染性病毒水平与这些结果一致。提高我们对环境条件如何影响流感病毒传染性和传播的理解，可能会揭示更好地保护公众免受流感病毒感染的方法。
The seasonality of influenza virus infections in temperate climates and the role of environmental conditions like temperature and humidity in the transmission of influenza virus through the air are not well understood. Using ferrets housed at four different environmental conditions, we evaluated the respiratory droplet transmission of two influenza viruses (a seasonal H3N2 virus and an H3N2 variant virus, the etiologic virus of a swine to human summertime infection) and concurrently characterized the aerosol shedding profiles of infected animals. Comparisons were made among the different temperature and humidity conditions and between the two viruses to determine if the H3N2 variant virus exhibited enhanced capabilities that may have contributed to the infections occurring in the summer. We report here that although increased levels of H3N2 variant virus were found in ferret nasal wash and exhaled aerosol samples compared to the seasonal H3N2 virus, enhanced respiratory droplet transmission was not observed under any of the environmental settings. However, overall environmental conditions were shown to modulate the frequency of influenza virus transmission through the air. Transmission occurred most frequently at 23°C/30%RH, while the levels of infectious virus in aerosols exhaled by infected ferrets agree with these results. Improving our understanding of how environmental conditions affect influenza virus infectivity and transmission may reveal ways to better protect the public against influenza virus infections.
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影响因子：
3.7
作者：
Huang SS;Banner D;Fang Y;Ng DC;Kanagasabai T;Kelvin DJ;Kelvin AA
通讯作者：
Kelvin AA
DOI：
10.1086/597073
发表时间：
2009-03-15
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Mubareka S;Lowen AC;Steel J;Coates AL;García-Sastre A;Palese P
通讯作者：
Palese P
影响因子：
6.7
作者：
Milton, Donald K.;Fabian, M. Patricia;McDevitt, James J.
通讯作者：
McDevitt, James J.
影响因子：
6.4
作者：
Maines, Taronna R.;Belser, Jessica A.;Tumpey, Terrence M.
通讯作者：
Tumpey, Terrence M.
影响因子：
4.3
作者：
Belser JA;Katz JM;Tumpey TM
通讯作者：
Tumpey TM