Transdiagnostic dimensions of anxiety and depression moderate motivation-related brain networks during goal maintenance.
Transdiagnostic dimensions of anxiety and depression moderate motivation-related brain networks during goal maintenance.
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DOI：
10.1002/da.22271
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发表时间：
2014-10
影响因子：
7.4
通讯作者：
Heller, Wendy
中科院分区：
文献类型：
--
作者：
Spielberg, Jeffrey M.;Miller, Gregory A.;Warren, Stacie L.;Sutton, Bradley P.;Banich, Marie;Heller, Wendy
关键词：
推进对精神病理学病因、预防和治疗的研究要求该领域超越神经功能障碍的模块化概念，转向理解关键脑网络中的障碍。尽管一些关于焦虑和抑郁的研究已经开始这样做，但它们通常存在一些缺点，包括：(1)一种忽视跨诊断过程的分类方法，(2)未能解释焦虑和抑郁的实质共病，(3)对静止网络的检查，忽略了只有在网络受到挑战时才会出现的破坏。因此，本研究考察了焦虑/抑郁的跨诊断维度与功能连接模式之间的关系，同时对目标维持提出了挑战。参与者（n = 179，未选择的社区成员和被选择为焦虑/抑郁程度高/低的大学生）在收集功能磁共振成像数据的同时执行一项挑战目标维持的任务（颜色词Stroop）。分析检查了焦虑/抑郁对先前与接近和回避动机相关的背外侧前额皮质（dlPFC）和杏仁核/眼窝前额皮质（OFC）区域之间条件依赖性耦合的调节作用。焦虑觉醒与杏仁核↔右侧dlPFC耦合呈正相关。抑郁与OFC↔右dlPFC耦合呈正相关，与OFC↔左dlPFC耦合负相关。研究结果通过识别在维持接近和回避目标的重要网络中与焦虑和抑郁相关的特定的、不同的功能障碍，将该领域推进到焦虑/抑郁的神经实例化的综合模型。具体而言，研究结果揭示了焦虑中的注意偏差和抑郁中的评价偏差的潜在神经机制，并强调了在网络受到挑战时检查焦虑/抑郁的跨诊断维度的重要性。
Advancing research on the etiology, prevention, and treatment of psychopathology requires the field to move beyond modular conceptualizations of neural dysfunction toward understanding disturbance in key brain networks. Although some studies of anxiety and depression have begun doing so, they typically suffer from several drawbacks, including: (1) a categorical approach ignoring transdiagnostic processes, (2) failure to account for substantial anxiety and depression comorbidity, (3) examination of networks at rest, which overlooks disruption manifesting only when networks are challenged. Accordingly, the present study examined relationships between transdiagnostic dimensions of anxiety/depression and patterns of functional connectivity while goal maintenance was challenged. Participants (n = 179, unselected community members and undergraduates selected to be high/low on anxiety/depression) performed a task in which goal maintenance was challenged (color-word Stroop) while fMRI data were collected. Analyses examined moderation by anxiety/depression of condition-dependent coupling between regions of dorsolateral prefrontal cortex (dlPFC) previously associated with approach and avoidance motivation and amygdala/orbitofrontal cortex (OFC). Anxious arousal was positively associated with amygdala↔right dlPFC coupling. Depression was positively associated with OFC↔right dlPFC coupling and negatively associated with OFC↔left dlPFC coupling. Findings advance the field toward an integrative model of the neural instantiation of anxiety/depression by identifying specific, distinct dysfunctions associated with anxiety and depression in networks important for maintaining approach and avoidance goals. Specifically, findings shed light on potential neural mechanisms involved in attentional biases in anxiety and valuation biases in depression and underscore the importance of examining transdiagnostic dimensions of anxiety/depression while networks are challenged.
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