White matter connectivity in children with autism spectrum disorders: a tract-based spatial statistics study.
White matter connectivity in children with autism spectrum disorders: a tract-based spatial statistics study.
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DOI：
10.1186/1471-2377-12-148
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发表时间：
2012-11-29
期刊：
影响因子：
2.6
通讯作者：
Muratori F
中科院分区：
文献类型：
--
作者：
Billeci L;Calderoni S;Tosetti M;Catani M;Muratori F
自闭症谱系障碍（ASD）与白色物质（WM）完整性的广泛改变有关。然而，虽然越来越多的研究揭示了高功能青少年和成人ASD的微结构WM改变，但文献仍然缺乏关于儿童和低功能ASD患者全脑结构连接的信息。本研究的目的是调查WM连接在ASD儿童和没有精神发育迟滞相比，典型的发展控制（TD）。对22例ASD患儿（平均年龄：5.54岁）和10例对照组（平均年龄：5.25岁）进行了弥散张量成像（DTI）。数据进行了分析，使用基于轨迹的空间统计（TBSS）和纤维束成像。相关性进行了研究，在确定的改变区域和生产性语言水平的WM微观结构之间。TBSS分析显示，在主要的WM途径的分数各向异性（FA）的广泛增加。纤维束成像方法显示，在扣带回和胼胝体中的纤维长度和FA增加，右弓状带和左扣带回的间接段的平均扩散率增加。平均扩散率也与表达性语言功能的弓状束的左间接段。我们的研究证实了在年轻的ASD儿童中存在几种结构连接异常。特别是，ASD患者特征性FA增加的TBSS特征扩展到儿童，这是先前仅在ASD幼儿中检测到的发现。检测到的WM完整性异常可能与ASD的病理生理学有关，因为所涉及的结构参与了该疾病的一些核心非典型特征。
Autism spectrum disorders (ASD) are associated with widespread alterations in white matter (WM) integrity. However, while a growing body of studies is shedding light on microstructural WM alterations in high-functioning adolescents and adults with ASD, literature is still lacking in information about whole brain structural connectivity in children and low-functioning patients with ASD. This research aims to investigate WM connectivity in ASD children with and without mental retardation compared to typically developing controls (TD). Diffusion tensor imaging (DTI) was performed in 22 young children with ASD (mean age: 5.54 years) and 10 controls (mean age: 5.25 years). Data were analysed both using the tract-based spatial statistics (TBSS) and the tractography. Correlations were investigated between the WM microstructure in the identified altered regions and the productive language level. The TBSS analysis revealed widespread increase of fractional anisotropy (FA) in major WM pathways. The tractographic approach showed an increased fiber length and FA in the cingulum and in the corpus callosum and an increased mean diffusivity in the indirect segments of the right arcuate and the left cingulum. Mean diffusivity was also correlated with expressive language functioning in the left indirect segments of the arcuate fasciculus. Our study confirmed the presence of several structural connectivity abnormalities in young ASD children. In particular, the TBSS profile of increased FA that characterized the ASD patients extends to children a finding previously detected in ASD toddlers only. The WM integrity abnormalities detected may be relevant to the pathophysiology of ASD, since the structures involved participate in some core atypical characteristics of the disorder.
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影响因子：
1.9
作者：
Casanova, MF;Buxhoeveden, DP;Brown, C
通讯作者：
Brown, C
影响因子：
5.7
作者：
Fletcher, P. Thomas;Whitaker, Ross T.;Tao, Ran;DuBray, Molly B.;Froehlich, Alyson;Ravichandran, Caitlin;Alexander, Andrew L.;Bigler, Erin D.;Lange, Nicholas;Lainhart, Janet E.
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影响因子：
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作者：
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通讯作者：
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DOI：
10.1111/j.1469-7610.2009.02086.x
发表时间：
2009-09-01
影响因子：
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作者：
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通讯作者：
McAlonan, G. M.
影响因子：
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作者：
Cheng, Yawei;Chou, Kun-Hsien;Lin, Ching-Po
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