Altered neural correlates of reward and loss processing during simulated slot-machine fMRI in pathological gambling and cocaine dependence.
Altered neural correlates of reward and loss processing during simulated slot-machine fMRI in pathological gambling and cocaine dependence.
复制标题
DOI：
10.1016/j.drugalcdep.2014.09.013
复制
发表时间：
2014-12-01
影响因子：
4.2
通讯作者：
Potenza, Marc N.
中科院分区：
文献类型：
--
作者：
Worhunsky, Patrick D.;Malison, Robert T.;Rogers, Robert D.;Potenza, Marc N.
赌博或物质使用障碍的个体在奖励回路中表现出类似的功能改变，这表明成瘾性障碍中存在共同的潜在脆弱性。对物质相关和非物质相关成瘾中奖励处理的常见和独特改变的进一步研究可能会确定这些疾病治疗开发中可能针对的神经因素。为了研究病理性赌博中的背景奖励加工，三组人进行了老虎机fMRI任务（病态赌博、可卡因依赖和两种疾病均无）; N=24），以确定两组成瘾者（非物质相关和物质相关）显示出彼此之间的相似性和差异，成瘾组在预期期间和以下交付的胜利，失败和'近错过'的结果。病理性赌博或可卡因依赖的人相比，那些既没有障碍表现出夸张的预期活动，在中脑边缘和腹侧皮质区，病理性赌博的参与者表现出更大的积极的可能回报的预期和可卡因依赖的参与者表现出更多的负面肯定损失的预期。临床样本均未表现出在健康对照参与者中观察到的近距离结果后的内侧额叶或纹状体反应。预期加工的改变可能对奖赏的效价敏感，并且是内容障碍特异性的。共同和独特的发现病理赌博和可卡因依赖方面的预期奖励和近错过损失处理建议共享和独特的元素，可能是有针对性的通过行为或药物干预治疗成瘾。
Individuals with gambling or substance-use disorders exhibit similar functional alterations in reward circuitry suggestive of a shared underlying vulnerability in addictive disorders. Additional research into common and unique alterations in reward-processing in substance-related and non-substance-related addictions may identify neural factors that could be targeted in treatment development for these disorders. To investigate contextual reward-processing in pathological gambling, a slot-machine fMRI task was performed by three groups (with pathological gambling, cocaine dependence and neither disorder; N=24 each) to determine the extent to which two groups with addictions (non-substance-related and substance-related) showed similarities and differences with respect to each other and a non-addicted group during anticipatory periods and following the delivery of winning, losing and ‘near-miss’ outcomes. Individuals with pathological gambling or cocaine dependence compared to those with neither disorder exhibited exaggerated anticipatory activity in mesolimbic and ventrocortical regions, with pathological-gambling participants displaying greater positive possible-reward anticipation and cocaine-dependent participants displaying more negative certain-loss anticipation. Neither clinical sample exhibited medial frontal or striatal responses that were observed following near-miss outcomes in healthy comparison participants. Alterations in anticipatory processing may be sensitive to the valence of rewards and content-disorder-specific. Common and unique findings in pathological gambling and cocaine dependence with respect to anticipatory reward and near-miss loss processing suggest shared and unique elements that might be targeted through behavioral or pharmacological interventions in the treatment of addictions.
登录
查看更多内容
影响因子：
2.4
作者：
Clark, Luke;Crooks, Ben;Dunn, Barnaby D.
通讯作者：
Dunn, Barnaby D.
影响因子：
5.7
作者：
Brown GG;Mathalon DH;Stern H;Ford J;Mueller B;Greve DN;McCarthy G;Voyvodic J;Glover G;Diaz M;Yetter E;Ozyurt IB;Jorgensen KW;Wible CG;Turner JA;Thompson WK;Potkin SG;Function Biomedical Informatics Research Network
通讯作者：
Function Biomedical Informatics Research Network
影响因子：
8.2
作者：
Leyton, Marco;Vezina, Paul
通讯作者：
Vezina, Paul
影响因子：
10.6
作者：
Jia, Zhiru;Worhunsky, Patrick D.;Carroll, Kathleen M.;Rounsaville, Bruce J.;Stevens, Michael C.;Pearlson, Godfrey D.;Potenza, Marc N.
通讯作者：
Potenza, Marc N.
影响因子：
3.4
作者：
Beck, AT;Steer, RA;Ranieri, WF
通讯作者：
Ranieri, WF