Solid fuel use is a major risk factor for acute coronary syndromes among rural women: a matched case control study.
Solid fuel use is a major risk factor for acute coronary syndromes among rural women: a matched case control study.
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DOI：
10.1016/j.puhe.2013.09.005
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发表时间：
2014-01
期刊：
影响因子：
5.2
通讯作者：
Sathiakumar N
中科院分区：
文献类型：
--
作者：
Fatmi Z;Coggon D;Kazi A;Naeem I;Kadir MM;Sathiakumar N
世界上几乎一半的人口使用固体燃料做饭，使妇女暴露在室内空气中的高度颗粒污染中。我们根据农村妇女使用固体燃料的情况，评估了她们患急性冠状动脉综合征（ACS）的风险。配对病例对照研究。数据收集在巴基斯坦农村地区的公立三级保健医院。将73例ACS患者与性别和年龄（± 5岁）匹配的对照组进行比较，对照组因其他原因入院。通过在访谈和测量身高和体重时进行问卷调查，确定用于烹饪的燃料和暴露于潜在的混杂变量。条件logistic回归用于估计比值比（OR）和95%置信区间（95%CI）。调整潜在混杂因素后，目前使用固体燃料与ACS密切相关（OR 4.8，95%CI：1.5至14.8），最后一次使用固体燃料超过15年的女性风险最低。ACS与当前使用固体燃料相关的人群归因分数为49.0%（95%CI：41.3% - 57.4%）。这些发现支持了这样的假设，即使用固体燃料造成的室内空气污染是ACS的重要原因。我们的研究证明了在农村妇女人口中进行病例对照研究来解决这个问题的可行性，并鼓励进行更大规模和统计上更有力的调查。
Almost half of the world’s population uses solid fuel for cooking, exposing women to high levels of particulate pollution in indoor air. We assessed the risk of acute coronary syndrome (ACS) among rural women, according to their use of solid fuel. Matched case control study. Data were collected at a public tertiary care hospital in a rural district of Pakistan. Seventy-three women with ACS were compared with controls, individually matched for sex and age (±5years), who were admitted to hospital for other reasons. Fuels used for cooking and exposures to potentially confounding variables were ascertained through a questionnaire administered at interview and measurement of height and weight. Conditional logistic regression was used to estimate odds ratios (ORs) with 95% confidence intervals (95% CIs). After adjustment for potential confounding factors, current use of solid fuel was strongly associated with ACS ( OR 4.8, 95% CI: 1.5 to 14.8), and risk was lowest in women who had last used solid fuel more than 15 years earlier. The population attributable fraction for ACS in relation to current use of solid fuel was 49.0% (95% CI: 41.3% - 57.4%). These findings support the hypothesis that indoor air pollution from use of solid fuel is an important cause of ACS. Our study demonstrates the feasibility of case-control studies in rural populations of women to address this question, and is an encouragement to larger and statistically more powerful investigations.
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