Hierarchical Control of Drosophila Sleep, Courtship, and Feeding Behaviors by Male-Specific P1 Neurons

Hierarchical Control of Drosophila Sleep, Courtship, and Feeding Behaviors by Male-Specific P1 Neurons
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雄性特异性 P1 神经元对果蝇睡眠、求爱和进食行为的分层控制

DOI:
10.1007/s12264-018-0281-z
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发表时间:
2018-09
影响因子:
5.6
通讯作者:
Pan Yufeng
Pan Yufeng
中科院分区:
医学2区
文献类型:
--
作者:
Zhang Wenxuan;Guo Chao;Chen D;an;Peng Qionglin;Pan Yufeng

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动物在睡眠、求偶和进食行为中的选择是基于外部感觉线索和内部状态的整合;这些选择对生存和繁殖至关重要。这些竞争行为密切相关,并由不同的神经回路控制,但它们是否也由共享的神经节点调节尚不清楚。在这里,我们研究了一组男性特定的P1神经元控制睡眠,求偶和果蝇雄性的进食行为。我们发现,P1神经元的轻度激活足以影响睡眠,但不影响求爱或进食,而由五分之四的独立驱动程序标记的P1神经元的较强激活诱导求爱,但只有针对最大数量的P1神经元的驱动程序影响进食。这些结果揭示了一个共同的神经节点,以阈值依赖的方式影响睡眠,求偶和进食,并提供了关于竞争行为如何通过共享神经节点进行调节的见解。
Animals choose among sleep, courtship, and feeding behaviors based on the integration of both external sensory cues and internal states; such choices are essential for survival and reproduction. These competing behaviors are closely related and controlled by distinct neural circuits, but whether they are also regulated by shared neural nodes is unclear. Here, we investigated how a set of male-specific P1 neurons controls sleep, courtship, and feeding behaviors in Drosophila males. We found that mild activation of P1 neurons was sufficient to affect sleep, but not courtship or feeding, while stronger activation of P1 neurons labeled by four out of five independent drivers induced courtship, but only the driver that targeted the largest number of P1 neurons affected feeding. These results reveal a common neural node that affects sleep, courtship, and feeding in a threshold-dependent manner, and provide insights into how competing behaviors can be regulated by a shared neural node.
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