Poly(1,8-octanediol citrate)/bioactive glass composite with improved mechanical performance and bioactivity for bone regeneration
Poly(1,8-octanediol citrate)/bioactive glass composite with improved mechanical performance and bioactivity for bone regeneration
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聚（1,8-辛二醇柠檬酸酯）/生物活性玻璃复合材料具有改善的机械性能和骨再生生物活性
DOI：
10.1016/j.cclet.2017.07.014
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发表时间：
2017-11
影响因子：
9.1
通讯作者：
Dong Qiu
中科院分区：
文献类型：
--
作者：
Hui-Hui Ren;Hui-Yu Zhao;Yang Cui;Xiang Ao;Ai-Ling Li;Zhong-Min Zhang;Dong Qiu
聚（1，8-辛二醇-共-柠檬酸盐）（POC）是一种新型的具有良好生物相容性和生物可降解性的聚酯，在软组织工程中得到了广泛的研究。但由于其力学性能差、生物活性低等缺点，限制了其在骨再生中的应用。在这项研究中，使用45 S5 Bioglass®和植酸衍生的生物活性玻璃（称为PSC）开发了一系列POC/生物活性玻璃（BG）复合材料。结果表明，BG中的钙通过形成二羧酸钙桥，增强了POC/BG复合材料的交联，从而提高了复合材料的力学性能。当使用PSC时，与具有45 S5 Bioglass®的复合材料相比，复合材料表现出显著更好的机械性能。例如，通过掺入70重量%的PSC，POC/PSC复合材料的压缩强度可以提高到约50 MPa和模量1.3 ± 0.1 GPa。此外，这些POC/PSC复合材料均表现出良好的体外生物活性和细胞生物相容性。在SD大鼠股骨髁缺损的组织学结果表明，POC/PSC样品与周围组织整合良好，并刺激骨再生。POC/PSC复合材料力学性能和生物活性的提高使其在骨再生方面具有潜在的应用前景。
Poly(1,8-octanediol-co-citrate) (POC) represents a new promising biocompatible and biodegradable polyester that has been extensively investigated for soft tissue engineering. However, the poor mechanical performance and poor bioactivity limit its application in bone regeneration. In this study, a series of POC/bioactive glasses (BG) composites were developed using 45S5 Bioglass®and a phytic acid-derived bioactive glass (referred as PSC). The results indicated that calcium in BG could enhance the crosslinking of the POC/BG composites by forming calcium dicarboxylate bridges and thus improve their mechanical performances. When PSC were used, the composites exhibited significantly better mechanical properties compared to composites with 45S5 Bioglass®. For example, by incorporating 70 wt% PSC, the compressive strength of POC/PSC composites could be improved to approximately 50 MPa and modulus 1.3 ± 0.1 GPa. Furthermore, all these POC/PSC composites showed goodin vitrobioactivity and cellular biocompatibility. Histology results in femoral condyle defects of Sprague-Dawley rats indicated that the POC/PSC samples integrated well with surrounding tissues and stimulated bone regeneration. The improved mechanical properties and bioactivity of POC/PSC composites make them promising for potential application in bone regeneration.
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DOI：
10.1002/jbm.a.35074
发表时间：
2014-11
期刊：
Journal of biomedical materials research. Part A
影响因子：
--
作者：
F. Shirazi;Ehsan Moghaddam;M. Mehrali;A. Oshkour;H. Metselaar;N. A. Kadri;Keivan Zandi;N. Abu
通讯作者：
F. Shirazi;Ehsan Moghaddam;M. Mehrali;A. Oshkour;H. Metselaar;N. A. Kadri;Keivan Zandi;N. Abu
DOI：
10.1002/jbm.b.31009
发表时间：
2008-07-01
影响因子：
3.4
作者：
Ghosh, Samir K.;Nandi, Samit K.;Basu, Debabrata
通讯作者：
Basu, Debabrata
影响因子：
29.4
作者：
Yang, J;Webb, AR;Ameer, GA
通讯作者：
Ameer, GA
DOI：
10.1007/s10856-011-4464-7
发表时间：
2011-12-01
影响因子：
3.7
作者：
Li, Ailing;Qiu, Dong
通讯作者：
Qiu, Dong
影响因子：
3.4
作者：
Jiao Y;Gyawali D;Stark JM;Akcora P;Nair P;Tran RT;Yang J
通讯作者：
Yang J