Atypical speech versus non-speech detection and discrimination in 4- to 6- yr old children with autism spectrum disorder: An ERP study.
Atypical speech versus non-speech detection and discrimination in 4- to 6- yr old children with autism spectrum disorder: An ERP study.
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DOI：
10.1371/journal.pone.0181354
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发表时间：
2017
期刊：
影响因子：
3.7
通讯作者：
McCleery JP
中科院分区：
文献类型：
--
作者：
Galilee A;Stefanidou C;McCleery JP
以前的事件相关电位（ERP）研究利用古怪的刺激范式表明减少处理的语音与非语音的声音在自闭症谱系障碍（ASD）的儿童。然而，这些语音处理异常背后的大脑机制，以及它们在多大程度上与这一人群的语言能力差有关仍然未知。在当前的研究中，我们利用一种新型的配对重复范式，与性别和语言年龄匹配的对照组相比，研究4至6岁自闭症谱系障碍儿童与言语和非言语声音检测和区分相关的ERP反应。当儿童被动地听成对的刺激时，记录ERP，这些刺激要么是两个语音声音，要么是两个非语音声音，语音接着非语音，或者非语音接着语音。对照组参与者表现出从颞电极测量的N330匹配/不匹配反应，反映了双侧的语音与非语音检测，而ASD儿童仅在左半球的颞电极上表现出这种效果。此外，虽然对照组在大约600 ms（中央N600，时间P600）时表现出匹配/不匹配的影响，当一个非语音的声音之后，由语音的声音，这些影响是不存在的ASD组。这些发现表明，ASD儿童在区分非言语刺激和言语刺激时，未能激活右半球机制，这可能与言语检测的社会或情感方面有关。总之，这些结果表明，非典型语音与非语音处理的存在与ASD儿童相比，典型的发展中国家的儿童匹配的语言年龄。
Previous event-related potential (ERP) research utilizing oddball stimulus paradigms suggests diminished processing of speech versus non-speech sounds in children with an Autism Spectrum Disorder (ASD). However, brain mechanisms underlying these speech processing abnormalities, and to what extent they are related to poor language abilities in this population remain unknown. In the current study, we utilized a novel paired repetition paradigm in order to investigate ERP responses associated with the detection and discrimination of speech and non-speech sounds in 4- to 6—year old children with ASD, compared with gender and verbal age matched controls. ERPs were recorded while children passively listened to pairs of stimuli that were either both speech sounds, both non-speech sounds, speech followed by non-speech, or non-speech followed by speech. Control participants exhibited N330 match/mismatch responses measured from temporal electrodes, reflecting speech versus non-speech detection, bilaterally, whereas children with ASD exhibited this effect only over temporal electrodes in the left hemisphere. Furthermore, while the control groups exhibited match/mismatch effects at approximately 600 ms (central N600, temporal P600) when a non-speech sound was followed by a speech sound, these effects were absent in the ASD group. These findings suggest that children with ASD fail to activate right hemisphere mechanisms, likely associated with social or emotional aspects of speech detection, when distinguishing non-speech from speech stimuli. Together, these results demonstrate the presence of atypical speech versus non-speech processing in children with ASD when compared with typically developing children matched on verbal age.
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影响因子：
4.9
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Dawson G;Bernier R;Ring RH
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