Bone marrow lesions are associated with altered trabecular morphometry.
Bone marrow lesions are associated with altered trabecular morphometry.
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DOI：
10.1016/j.joca.2012.08.013
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发表时间：
2012-12
影响因子：
7
通讯作者：
McAlindon, T. E.
中科院分区：
文献类型：
--
作者：
Driban, J. B.;Tassinari, A.;Lo, G. H.;Price, L. L.;Schneider, E.;Lynch, J. A.;Eaton, C. B.;McAlindon, T. E.
骨髓病变（BML）是骨关节炎患者常见的磁共振（MR）特征，但其病理基础仍知之甚少，尚未进行体内评价。我们的目的是使用基于定量MR的小梁形态测量来评估与相同感兴趣区域（ROI）中存在的BML的存在和大小相关的小梁结构。骨关节炎倡议（OAI）的158名参与者在与OAI 3 T MR膝关节评价相同的会话中使用冠状面3D FISP序列进行骨小梁形态测量成像。对这些膝关节3D FISP图像上中央负重ROI中的近端内侧胫骨软骨下骨的表观骨体积分数、骨小梁数量、间距和厚度进行定量评价。还在紧邻关节软骨的软骨下骨中评价了BML。还在相同的小梁形态测量ROI内评价了BML体积，并将其半定量分类为无、小或大。Kruskal-Wallis检验用于确定平均表观骨体积分数、骨小梁数量、间距或厚度是否因BML评分而不同。与ROI不含BML的膝关节相比，BML较小或较大的膝关节具有统计学上更高的表观骨体积分数（p<0.01）、骨小梁数量（p<0.01）和厚度（p=0.02），以及更低的骨小梁间距（p<0.01）。与ROI不含BML的膝关节相比，ROI含小或大BML的膝关节表观骨体积分数、骨小梁数量和厚度较高，但骨小梁间距较低。这些发现可能代表局部骨重建或压缩增加的区域。
Bone marrow lesions (BMLs) are a common magnetic resonance (MR) feature in patients with osteoarthritis, however their pathological basis remains poorly understood and has not been evaluated in vivo. Our aim was to evaluate the trabecular structure associated with the presence and size of BMLs present in the same regions of interest (ROI) using quantitative MR-based trabecular morphometry. 158 participants in the Osteoarthritis Initiative (OAI) were imaged with a coronal 3D FISP sequence for trabecular morphometry in the same session as the OAI 3T MR knee evaluation. The proximal medial tibial subchondral bone in the central weight-bearing ROI on these knee 3D FISP images were quantitatively evaluated for apparent bone volume fraction, trabecular number, spacing, and thickness. BMLs were also evaluated in the subchondral bone immediately adjacent to the articular cartilage. BML volume was also evaluated within the same trabecular morphometry ROI and semi-quantitatively classified as none, small, or large. Kruskal-Wallis test was used to determine if mean apparent bone volume fraction, trabecular number, spacing, or thickness differed by BML score. Compared to knees with ROIs containing no BMLs, knees with small or large BMLs had statistically higher apparent bone volume fraction (p<0.01), trabecular number (p<0.01), and thickness (p=0.02), and lower trabecular spacing (p<0.01). Compared to knees with ROIs containing no BMLs, knees with ROIs containing small or large BMLs had higher apparent bone volume fraction, trabecular number and thickness, but lower trabecular spacing. These findings may represent areas of locally increased bone remodeling or compression.
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影响因子：
4.7
作者：
Kothari, Ami;Guermazi, Ali;Chmiel, Joan S.;Dunlop, Dorothy;Song, Jing;Almagor, Orit;Marshall, Meredith;Cahue, September;Prasad, Pottumarthi;Sharma, Leena
通讯作者：
Sharma, Leena
影响因子：
7
作者：
Lindsey, CT;Narasimhan, A;Majumdar, S
通讯作者：
Majumdar, S
影响因子：
7
作者：
Blumenkrantz, G;Lindsey, CT;Majumdar, S
通讯作者：
Majumdar, S
影响因子：
19.7
作者：
Link, TM;Steinbach, LS;Majumdar, S
通讯作者：
Majumdar, S
影响因子：
7
作者：
Bolbos, R. I.;Zuo, Jin;Majumdar, Sharmila
通讯作者：
Majumdar, Sharmila