Use it or lose it: environmental enrichment as a means to promote successful cognitive aging.
Use it or lose it: environmental enrichment as a means to promote successful cognitive aging.
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DOI：
10.1100/tsw.2010.111
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发表时间：
2010-06-16
影响因子：
--
通讯作者：
Benoit JD
中科院分区：
文献类型：
--
作者：
Frick KM;Benoit JD
环境富集已越来越多地用于衰老和神经退行性疾病的啮齿动物模型中，以预防或逆转认知衰退和神经元功能障碍。然而，这方面的工作对人类认知老化的潜在应用很少被讨论。本文提供了一个概述啮齿类动物的研究，测试了环境丰富的海马和新皮层功能的影响，以及这些脑区介导的记忆类型。虽然来自神经退行性疾病模型的数据被提出，但主要重点是对老龄啮齿动物的研究和方法学问题（例如，年龄、治疗持续时间、治疗类型）对强化治疗的记忆有效性至关重要。这项工作对人类认知老化的影响进行了讨论。
Environmental enrichment has become increasingly utilized in rodent models of aging and neurodegenerative disease in order to prevent or reverse cognitive decline and neuronal dysfunction. However, the potential application of this body of work to human cognitive aging has rarely been discussed. The present article provides an overview of the rodent research that has tested the effects of environmental enrichment on hippocampal and neocortical function, and the types of memories mediated by these brain regions. Although data from models of neurodegenerative disease are presented, primary emphasis is given to studies of aging rodents and to methodological issues (e.g., age, treatment duration, treatment type) central to the mnemonic effectiveness of enrichment treatment. The implications of this work for human cognitive aging are discussed.
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影响因子：
3.5
作者：
Erickson, Kirk I.;Prakash, Ruchika S.;Voss, Michelle W.;Chaddock, Laura;Hu, Liang;Morris, Katherine S.;White, Siobhan M.;Wojcicki, Thomas R.;McAuley, Edward;Kramer, Arthur F.
通讯作者：
Kramer, Arthur F.
影响因子：
2.1
作者：
Ding, Yun-Hong;Li, Jie;Ding, Yuchuan
通讯作者：
Ding, Yuchuan
影响因子：
2.9
作者：
Chen, YC;Chen, QS;Wang, SL
通讯作者：
Wang, SL
影响因子：
64.8
作者：
CUMMINS, RA;WALSH, RN;HORSFALL, CR
通讯作者：
HORSFALL, CR
影响因子：
2.5
作者：
DIAMOND, MC;LINDNER, B;RAYMOND, A
通讯作者：
RAYMOND, A