The relationship between polycystic ovary syndrome, glucose tolerance status and serum preptin level.
The relationship between polycystic ovary syndrome, glucose tolerance status and serum preptin level.
复制标题
多囊卵巢综合征、糖耐量状态与血清preptin水平的关系
DOI：
10.1186/1477-7827-10-10
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发表时间：
2012-02-06
期刊：
影响因子：
--
通讯作者：
Zhang H
中科院分区：
文献类型：
--
作者：
Bu Z;Kuok K;Meng J;Wang R;Xu B;Zhang H
背景多囊卵巢综合征（PCOS）与肥胖、糖耐量异常和糖尿病有关.近年来研究发现preptin可促进大鼠胰岛素分泌，并可能在人类糖尿病和多囊卵巢综合征的发病机制中发挥作用。本研究的目的是评估PCOS、糖耐量状态和血清preptin水平之间的关系。MethodsThis study was carried out in a university-affiliated hospital from October 2010 to August 2011.分析了63例PCOS患者的人体测量参数、性激素浓度、血压、血脂、空腹血糖和胰岛素、糖负荷后2小时血糖（2 hOGTT）、糖化血红蛋白（HbA 1c）、稳态模型评估胰岛素抵抗指数（HOMA-IR）和血清preptin。其中糖耐量正常（NGT）妇女33例，糖耐量减低（IGT）妇女30例;非PCOS患者63例，其中糖耐量正常（NGT）妇女35例，糖耐量减低（IGT）妇女28例。对于PCOS患者和非PCOS患者，IGT女性的血清preptin水平高于NGT女性。PCOS患者血清Preptin水平高于非PCOS患者，但差异无统计学意义。在对合并数据的简单回归分析中，空腹血清preptin水平与TG、SBP、DBP、FBG、2 hOGTT和HOMA-IR呈正相关。多元逐步回归分析显示，preptin水平与糖耐量相关，与PCOS无关。结论无论PCOS状态如何，IGT妇女血清preptin水平均高于NGT妇女。Preptin水平与糖耐量相关，与PCOS无关。
BackgroundPolycystic ovary syndrome (PCOS) is linked to obesity, impaired glucose tolerance and diabetes. Recently, studies have found that preptin enhances insulin secretion in rats and might play a role in the pathogenesis of diabetes and PCOS in humans. The aim of this study was to evaluate the relationship between PCOS, glucose tolerance status, and serum preptin level.MethodsThis study was conducted in a university-affiliated hospital from October 2010 to August 2011. Anthropometric parameters, sex hormone concentrations, blood pressure, lipid profiles, fasting glucose and insulin, 2-h blood glucose after glucose overloaded (2hOGTT), glycosylated haemoglobin (HbA1c), homeostasis model assessment-insulin resistance index (HOMA-IR), and serum preptin of the samples were analyzed.ResultsSixty-three PCOS patients, including 33 women with normal glucose tolerance (NGT) and 30 women with impaired glucose tolerance (IGT), and 63 patients without PCOS, including 35 women with NGT and 28 women with IGT were recruited in this study. For patients with and without PCOS, women with IGT had higher serum preptin levels compared with women with NGT. Preptin levels in PCOS patients were higher compared with patients without PCOS, but the difference was not significant. Fasting serum preptin levels correlated positively with TG, SBP, DBP, FBG, 2hOGTT, and HOMA-IR in simple regression analysis of the pooled data. While in multiple stepwise regression analysis, preptin levels were independently related with glucose tolerance, but not with PCOS.ConclusionsIrrespective of PCOS status, women with IGT had higher serum preptin levels compared with women with NGT. Preptin levels are related with glucose tolerance status, but not with PCOS status.
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影响因子：
4.1
作者：
Buchanan, CM;Phillips, ARJ;Cooper, GJS
通讯作者：
Cooper, GJS
影响因子：
6.1
作者：
Fauser, BCJM;Chang, J;Lobo, R
通讯作者：
Lobo, R
影响因子：
2.9
作者：
Aslan, M.;Celik, O.;Kafkasli, A.
通讯作者：
Kafkasli, A.
影响因子：
4
作者：
Beydoun, Hind A.;Stadtmauer, Laurel;Beydoun, May A.;Russell, Helena;Zhao, Yueqin;Oehninger, Sergio
通讯作者：
Oehninger, Sergio
影响因子：
4.4
作者：
Yang, Gangyi;Li, Ling;Li, Ke
通讯作者：
Li, Ke