Current analysis of hypoxic-ischemic encephalopathy research issues and future treatment modalities.

Current analysis of hypoxic-ischemic encephalopathy research issues and future treatment modalities.
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DOI:
10.3389/fnins.2023.1136500
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发表时间:
2023
影响因子:
4.3
通讯作者:
Xiong, Liu-Lin
Xiong, Liu-Lin
中科院分区:
医学2区
文献类型:
--
作者:
She, Hong-Qing;Sun, Yi-Fei;Chen, Li;Xiao, Qiu-Xia;Luo, Bo-Yan;Zhou, Hong-Su;Zhou, Di;Chang, Quan-Yuan;Xiong, Liu-Lin

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缺氧缺血性脑病(HIE)是新生儿和成人长期神经功能障碍的主要原因。通过文献计量分析,我们分析了不同国家、机构和作者对HIE的研究现状。同时,我们对动物HIE模型和建模方法进行了广泛的总结。对HIE的神经保护治疗有不同的看法,临床主要的治疗方法是治疗性低温,但其疗效仍有待研究。因此,在本研究中,我们讨论了神经回路、损伤脑组织、神经回路相关技术的进展,为神经内分泌和神经保护相结合的HIE治疗和预后管理提供了新的思路。
Hypoxic-ischemic encephalopathy (HIE) is the leading cause of long-term neurological disability in neonates and adults. Through bibliometric analysis, we analyzed the current research on HIE in various countries, institutions, and authors. At the same time, we extensively summarized the animal HIE models and modeling methods. There are various opinions on the neuroprotective treatment of HIE, and the main therapy in clinical is therapeutic hypothermia, although its efficacy remains to be investigated. Therefore, in this study, we discussed the progress of neural circuits, injured brain tissue, and neural circuits-related technologies, providing new ideas for the treatment and prognosis management of HIE with the combination of neuroendocrine and neuroprotection.
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