Effects of juvenile exposure to predator odor on adolescent and adult anxiety and pain nociception.
Effects of juvenile exposure to predator odor on adolescent and adult anxiety and pain nociception.
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DOI：
10.1016/j.physbeh.2014.04.009
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发表时间：
2014-05-28
影响因子：
2.9
通讯作者：
Bloom CM
中科院分区：
文献类型：
--
作者：
Post RJ;Dahlborg KM;O'Loughlin LE;Bloom CM
临床研究人员跟踪了早期生活创伤的患者，并注意到广泛性焦虑症，单相抑郁症和冒险行为在青春期后期和成年早期发展。动物模型提供了一个机会，研究神经和发育过程的基础之间的关系，早期压力和后来的异常行为。本模型使用重复暴露于2，3，5-三甲基-3-噻唑啉（TMT）（狐狸粪便的一种成分）作为无条件的恐惧诱发刺激，以诱导出生后第23天（PND）至27天的幼年大鼠的应激。在青少年阶段（PND 42）的进一步身体成熟特征后，使用高架十字迷宫（ESTA）测试动物的焦虑和足底测试（Hargreaves方法）的疼痛，以评估青少年应激的任何持续影响。为了评估生活后期的额外压力如何影响焦虑和疼痛伤害感受，将PND 43大鼠暴露于不可避免的电击（0.8mA），并再次进行足底测试。在成年（PND 63）大鼠中进行最终测试期，以评估成年行为的变化。TMT暴露组大鼠在青春期比对照组更焦虑，但这种差异在暴露于次级应激源后消失。在成年期，但不是在青春期，TMT暴露的大鼠表现出较低的疼痛敏感性比对照组。这些结果表明，早期生活压力可以在以后的焦虑和疼痛伤害感受中发挥重要作用，并提供对焦虑和创伤相关疾病的发展和表现的深入了解。
Clinical researchers have tracked patients with early life trauma and noted generalized anxiety disorder, unipolar depression, and risk-taking behaviors developing in late adolescence and into early adulthood. Animal models provide an opportunity to investigate the neural and developmental processes that underlie the relationship between early stress and later abnormal behavior. The present model used repeated exposure to 2,3,5-trimethyl-3-thiazoline (TMT), a component of fox feces, as an unconditioned fear-eliciting stimulus in order to induce stress in juvenile rats aged postnatal day (PND) 23 through 27. After further physical maturation characteristic of the adolescent stage (PND 42), animals were tested using an elevated plus maze (EPM) for anxiety and plantar test (Hargreaves method) for pain to assess any lingering effects of the juvenile stress. To assess how an additional stress later in life affects anxiety and pain nociception, PND 43 rats were exposed to inescapable shock (0.8 mA) and again tested on EPM and plantar test. A final testing period was conducted in the adult (PND 63) rats to assess resulting changes in adult behaviors. TMT-exposed rats were significantly more anxious in adolescence than controls, but this difference disappeared after exposure to the secondary stressor. In adulthood, but not in adolescence, TMT-exposed rats demonstrated lower pain sensitivity than controls. These results suggest that early life stress can play a significant role in later anxiety and pain nociception, and offer insight into the development and manifestation of anxiety- and trauma-related disorders.
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影响因子：
2.9
作者：
VANDIJKEN, HH;MOS, J;TILDERS, FJH
通讯作者：
TILDERS, FJH
影响因子：
7.4
作者：
JORUM, E
通讯作者：
JORUM, E
影响因子：
8.2
作者：
Andersen, SL
通讯作者：
Andersen, SL
影响因子：
--
作者：
Kessler, RC;Berglund, P;Walters, EE
通讯作者：
Walters, EE
影响因子：
3
作者：
PELLOW, S;CHOPIN, P;BRILEY, M
通讯作者：
BRILEY, M