Gray matter volumetric correlates of dimensional impulsivity traits in children: Sex differences and heritability.
Gray matter volumetric correlates of dimensional impulsivity traits in children: Sex differences and heritability.
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DOI：
10.1002/hbm.25810
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发表时间：
2022-06-01
影响因子：
4.8
通讯作者：
Li, Chiang-Shan R.
中科院分区：
文献类型：
--
作者：
Chen, Yu;Ide, Jaime S.;Li, Clara S.;Chaudhary, Shefali;Le, Thang M.;Wang, Wuyi;Zhornitsky, Simon;Zhang, Sheng;Li, Chiang-Shan R.
先前的研究主要在中等大小的样本中调查了冲动性的大脑体积相关性，很少研究冲动性维度、性别差异或相关性遗传性的明显相关性。在这里，我们对青少年大脑认知发展项目策划的数据（n = 11,474；5,452 名女孩，9-10 岁）进行了基于体素的形态测量分析。在以所有 5 个 UPPS-P 子分数作为回归量，以月份为单位的年龄、颅内总体积、研究部位和扫描仪模型作为协变量的线性回归中，较高程度的缺乏预谋和感觉寻求与较大的皮质和皮质下灰质体积 (GMV) 相关。相比之下，在许多相同地区，较高的积极紧迫性与较小的 GMV 相关。维度冲动特征还涉及不同的体积相关性，例如，感觉寻求和积极紧迫感分别特别涉及双侧尾状头/中扣带皮层和双侧眶额皮质/左中央前回。相对于女孩，男孩在所有冲动维度上得分更高。相对于男孩，女孩在感觉寻求与岛叶、壳核和额下回 (IFG) GMV 之间以及正紧迫性与扣带皮层、岛叶和 IFG GMV 之间分别表现出显着更强的正相关性和负相关性。对于双胞胎子样本，尺寸冲动特征在女孩和男孩中均具有弱到中度遗传性，并且 GMV 相关性在女孩和男孩中具有高度遗传性。这些发现共同表明维度冲动特征的大脑体积基础存在共享和非共享以及性别差异，并可能促进儿童外化精神病理学的研究。消极紧迫感、缺乏预谋、缺乏毅力、寻求感觉和积极紧迫感涉及共享和非共享的体积相关性以及体积相关性中的性别差异。维度冲动特征在女孩和男孩中均具有弱到中度的遗传性，而 GMV 相关性在女孩和男孩中具有高度遗传性。
Previous research investigated the cerebral volumetric correlates of impulsivity largely in moderate‐sized samples and few have examined the distinct correlates of dimensions of impulsivity, sex differences, or heritability of the correlates. Here, we performed voxel‐based morphometry analysis of data (n = 11,474; 5,452 girls, 9–10 years) curated from the Adolescent Brain Cognition Development project. In a linear regression with all five UPPS‐P subscores as regressors and age in months, total intracranial volume, study site, and scanner model as covariates, higher levels of lack of premeditation, and sensation seeking were correlated with larger cortical and subcortical gray matter volumes (GMVs). In contrast, higher positive urgency was correlated with smaller GMVs in many of the same regions. The dimensional impulsivity traits also involved distinct volumetric correlates, with, for instance, sensation seeking and positive urgency specifically implicating bilateral caudate head/mid‐cingulate cortex and bilateral lateral orbitofrontal cortex/left precentral gyrus, respectively. Boys relative to girls scored higher in all impulsivity dimensions. Girls relative to boys showed significantly stronger positive and negative correlations between sensation seeking and insula, putamen, and inferior frontal gyrus (IFG) GMVs and between positive urgency and cingulate cortex, insula, and IFG GMVs, respectively. With a subsample of twins, the dimensional impulsivity traits were weakly to moderately heritable in both girls and boys, and the GMV correlates were highly heritable in girls and boys combined. These findings collectively suggest shared and nonshared as well as sex differences in the cerebral volumetric bases of dimensional impulsivity traits and may facilitate research of externalizing psychopathology in children. Negative urgency, lack of premeditation, lack of perseverance, sensation seeking, and positive urgency involve both shared and nonshared volumetric correlates as well as sex differences in the volumetric correlates. The dimensional impulsivity traits are weakly‐to‐moderately heritable in both girls and boys, and the GMV correlates are highly heritable in girls and boys combined.
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影响因子：
22.4
作者：
Cross, Catharine P.;Copping, Lee T.;Campbell, Anne
通讯作者：
Campbell, Anne
影响因子：
2.7
作者：
Cho, Sang Soo;Pellecchia, Giovanna;Strafella, Antonio P.
通讯作者：
Strafella, Antonio P.
DOI：
10.1016/j.addicn.2021.100003
发表时间：
2022-03-01
期刊：
Addiction neuroscience
影响因子：
--
作者：
Chen, Yu;Chaudhary, Shefali;Li, Chiang-Shan R
通讯作者：
Li, Chiang-Shan R
影响因子：
2.6
作者：
Chen, Yu;Chen, Caiqi;Fan, Jin
通讯作者：
Fan, Jin
影响因子：
4.7
作者：
Casey BJ;Cannonier T;Conley MI;Cohen AO;Barch DM;Heitzeg MM;Soules ME;Teslovich T;Dellarco DV;Garavan H;Orr CA;Wager TD;Banich MT;Speer NK;Sutherland MT;Riedel MC;Dick AS;Bjork JM;Thomas KM;Chaarani B;Mejia MH;Hagler DJ Jr;Daniela Cornejo M;Sicat CS;Harms MP;Dosenbach NUF;Rosenberg M;Earl E;Bartsch H;Watts R;Polimeni JR;Kuperman JM;Fair DA;Dale AM;ABCD Imaging Acquisition Workgroup
通讯作者：
ABCD Imaging Acquisition Workgroup