Chronic wireless neural population recordings with common marmosets.
Chronic wireless neural population recordings with common marmosets.
复制标题
DOI：
10.1016/j.celrep.2021.109379
复制
发表时间：
2021-07-13
期刊：
影响因子：
8.8
通讯作者：
Hatsopoulos NG
中科院分区：
文献类型：
--
作者：
Walker JD;Pirschel F;Sundiang M;Niekrasz M;MacLean JN;Hatsopoulos NG
绒猴是神经科学中越来越重要的模型系统，部分原因是由于无脑新皮层的遗传易驾驭性和增强的皮层可及性。然而，许多通常用于记录灵长类动物神经活动的技术抑制了绒猴自然行为的表达，从而妨碍了神经生理学的研究。为了应对这一挑战，我们已经开发出了记录无限制绒猴在多种行为学行为、多种大脑状态和多年时间内神经群体活动的方法。值得注意的是，我们灵活的方法设计允许更换电极阵列和移除植入物，提供替代实验终点。我们通过记录自由移动的绒猴在其自然行为和睡眠过程中的感觉运动皮层群体活动来验证该方法。在非人类灵长类动物的工作中常见的实验压力可能是用绒猴进行神经科学实验的限制因素。步行者等人设计了一种方法，允许在一系列自然行为和睡眠期间从绒猴大脑进行长期无线记录，对绒猴的干扰最小。
Marmosets are an increasingly important model system for neuroscience in part due to genetic tractability and enhanced cortical accessibility, due to a lissencephalic neocortex. However, many of the techniques generally employed to record neural activity in primates inhibit the expression of natural behaviors in marmosets precluding neurophysiological insights. To address this challenge, we have developed methods for recording neural population activity in unrestrained marmosets across multiple ethological behaviors, multiple brain states, and over multiple years. Notably, our flexible methodological design allows for replacing electrode arrays and removal of implants providing alternative experimental endpoints. We validate the method by recording sensorimotor cortical population activity in freely moving marmosets across their natural behavioral repertoire and during sleep. Experimental stressors common in work with non-human primates can be limiting factors in neuroscience experiments with marmosets. Walker et al. designed an approach to allow for chronic wireless recordings from the marmoset brain across a range of natural behaviors and during sleep with minimal disturbance to the marmosets.
登录
查看更多内容
影响因子：
2.5
作者：
Burman, Kathleen J.;Bakola, Sophia;Rosa, Marcello G. P.
通讯作者：
Rosa, Marcello G. P.
影响因子：
3
作者：
Chen X;Possel JK;Wacongne C;van Ham AF;Klink PC;Roelfsema PR
通讯作者：
Roelfsema PR
影响因子：
3
作者：
Lanz, F.;Lanz, X.;Rouiller, E. M.
通讯作者：
Rouiller, E. M.
影响因子：
2.5
作者：
Adams, Daniel L.;Economides, John R.;Horton, Jonathan C.
通讯作者：
Horton, Jonathan C.
影响因子：
3
作者：
Eliades, Steven J.;Wang, Xiaoqin
通讯作者：
Wang, Xiaoqin