Resting energy expenditure in patients with intermittent claudication and critical limb ischemia.
Resting energy expenditure in patients with intermittent claudication and critical limb ischemia.
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DOI：
10.1016/j.jvs.2009.12.072
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发表时间：
2010-06
影响因子：
4.3
通讯作者：
Montgomery, Polly S.
中科院分区：
文献类型：
--
作者：
Gardner, Andrew W.;Montgomery, Polly S.
主要目的是比较间歇性跛行和严重肢体缺血患者的静息能量消耗。第二个目的是确定静息能量消耗的预测因子，100例间歇性跛行患者和40例严重肢体缺血患者参加了本研究。评估患者的静息能量消耗、身体成分、踝/臂指数（ABI）和小腿血流。严重肢体缺血患者的静息能量消耗低于间歇性跛行患者（1429 ± 190 kcal/天vs. 1563 ± 229 kcal/天; p = 0.004），以及更高的体脂百分比（34.8 ± 7.8% vs. 31.5 ± 7.8%; p = 0.037），脂肪量较高（30.0 ± 9.3 kg vs. 26.2 ± 8.9 kg; p = 0.016），ABI较低（0.31 ± 0.11 vs. 0.79 ± 0.23; p < 0.001）。静息能量消耗由去脂体重（p < 0.0001）、年龄（p < 0.0001）、ABI（p < 0.0001）、种族（p <0.0001）、小牛血流量（p = 0.005）和糖尿病（p = 0.008）预测。在调整临床特征和去脂体重后，严重肢体缺血患者的静息能量消耗仍然较低（1473 ± 27.8千卡/天[平均值± SEM] vs. 1527 ± 19.3千卡/天; p = 0.031），但在进一步调整ABI和小腿血流后，组间不再有差异（1494 ± 25.2 kcal/天vs. 1505 ± 17.7 kcal/天（p = 0.269））。静息能量消耗随着PAD症状从间歇性跛行到严重肢体缺血的进展而降低。此外，最易受静息能量消耗下降影响的严重肢体缺血患者是年龄较大的非裔美国糖尿病患者。严重肢体缺血患者的静息能量消耗较低，加上他们久坐不动的生活方式，表明他们长期处于正能量平衡和体重增加的高风险中。
The primary aim was to compare the resting energy expenditure of patients with intermittent claudication and critical limb ischemia. A secondary aim was to identify predictors of resting energy expenditure, One hundred patients limited by intermittent claudication and 40 patients with critical limb ischemia participated in this study. Patients were assessed on resting energy expenditure, body composition, ankle/brachial index (ABI), and calf blood flow. Patients with critical limb ischemia had a lower resting energy expenditure than patients with intermittent claudication (1429 ± 190 kcal/day vs. 1563 ± 229 kcal/day; p = 0.004), as well as higher body fat percentage (34.8 ± 7.8% vs. 31.5 ± 7.8%; p = 0.037), higher fat mass (30.0 ± 9.3 kg vs. 26.2 ± 8.9 kg; p = 0.016), and lower ABI (0.31 ± 0.11 vs. 0.79 ± 0.23; p < 0.001). Resting energy expenditure was predicted by fat free mass (p < 0.0001), age (p < 0.0001), ABI (p < 0.0001), ethnicity (p < 0.0001), calf blood flow (p = 0.005), and diabetes (p = 0.008). Resting energy expenditure remained lower in the patients with critical limb ischemia after adjusting for clinical characteristics plus fat free mass (1473 ± 27.8 kcal/day [mean ± SEM] vs. 1527 ± 19.3 kcal/day; p = 0.031), but was no longer different between groups after further adjustment for ABI and calf blood flow (1494 ± 25.2 kcal/day vs. 1505 ± 17.7 kcal/day (p = 0.269). Resting energy expenditure is decreased with a progression in PAD symptoms from intermittent claudication to critical limb ischemia. Furthermore, patients with critical limb ischemia who are most susceptible for decline in resting energy expenditure are older, African-American patients with diabetes. The lower resting energy expenditure of patients with critical limb ischemia, combined with their sedentary lifestyle, suggests that they are at high risk for long-term positive energy balance and weight gain.
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影响因子：
9.6
作者：
CHEATLE, TR;POTTER, LA;SCURR, JH
通讯作者：
SCURR, JH
影响因子：
4.3
作者：
Gardner, Andrew W.;Montgomery, Polly S.;Parker, Donald E.
通讯作者：
Parker, Donald E.
影响因子：
4.9
作者：
Gougeon, R;Lamarche, M;Venuta, T
通讯作者：
Venuta, T
影响因子：
4.3
作者：
Gardner, Andrew W.;Montgomery, Polly S.
通讯作者：
Montgomery, Polly S.
影响因子：
2.8
作者：
Gardner, AW;Killewich, LA;Fonong, T
通讯作者：
Fonong, T