Dose ranging effects of vitamin D3 on the geriatric depression score: A clinical trial.
Dose ranging effects of vitamin D3 on the geriatric depression score: A clinical trial.
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DOI：
10.1016/j.jsbmb.2017.10.025
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发表时间：
2018-04
期刊：
影响因子：
--
通讯作者：
Gallagher JC
中科院分区：
文献类型：
--
作者：
Yalamanchili V;Gallagher JC
抑郁症是影响数百万人的常见问题，通常用选择性5-羟色胺摄取抑制剂治疗。维生素D作为一种联合治疗的兴趣是由一些关联研究激发的，这些研究将抑郁症与低血清25 OHD水平相关联。很少有关于维生素D和抑郁症的纵向研究，大多数是单剂量的维生素D。在这项研究中，我们检查了一年的治疗与几个剂量的维生素D对老年抑郁症评分（GDS）在老年白人和非洲裔美国妇女的影响。该临床试验是一项在黑人和白色老年妇女中进行的7种每日口服剂量维生素D（400- 4800 IU/d）的研究。该试验为双盲、随机和安慰剂对照试验，持续12个月。主要入选标准为血清25羟维生素D（25 OHD）≤ 20 ng/ml（50 nmo/L）。给予钙补充剂，以维持年轻人每天1000毫克的钙摄入量和老年妇女每天1200-1400毫克的钙摄入量。在基线和12个月时，使用经验证的长表收集老年抑郁症（GDS）数据。血清25 OHD的变化是主要结局，GDS是次要结局之一。对相关协变量进行了调整。与安慰剂相比，按低、中和高剂量或按五分位数分析维生素D的作用。在最高剂量4800 IU时，血清25 OHD呈二次曲线函数增加，白色女性的平均值为46 ng/ml（115 nmol/L），黑人女性为49 ng/ml（122.5 nmol/L）。在老年女性中，白人的平均GDS评分从基线时的3.8（SD±4.2）变为12个月时的3.6（SD±4.1），黑人的平均GDS评分从3.0（SD±3.7）变为3.02（SD±4.2）。（白人p = 0.790;黑人p=0.958）。12个月后，在接受不同剂量维生素D治疗的女性中，剂量对GDS评分的变化没有影响（白人p=0.507，黑人p=0.340）。当白人和非裔美国人被分为3个剂量组时，低剂量组（400-800 IU）、中剂量组（1600-3200 IU）和高剂量组（4000-4800 IU），低剂量组评分变化为0.8，中剂量组为-0.30，高剂量组为-0.31，而安慰剂组为0.11（p=0.546）。总之，无论是增加维生素D剂量还是血清25 OHD达到应答的五分位数，高加索人或非裔美国人的GDS评分均无改善。这些变化很小，也不显著，可能是因为这些群体中抑郁症女性的数量相对较少。进一步的研究应该招募更多的人，3个剂量组，覆盖20- 60 ng/ml的血清25 OHD范围，以及更多的临床抑郁症受试者，以充分解决维生素D对抑郁症的影响问题。
Depression is a common problem affecting millions, usually treated with selective serotonin uptake inhibitors. Interest in vitamin D as a co-therapy was stimulated by some association studies that correlated depression with low serum 25OHD levels. There are few longitudinal studies of vitamin D and depression and most are single doses of vitamin D. In this study we examined the effect of one-year treatment with several doses of vitamin D on the Geriatric depression score (GDS) in older Caucasian and African American women. The clinical trial was a study of seven daily oral doses of vitamin D (400-4800IU/d) in Black and White older women. The trial was a double blind, randomized and placebo controlled lasting 12-months. The main inclusion criterion was serum 25 hydroxyvitamin D (25OHD) ≤ 20ng/ml (50nmo/L). Calcium supplements were given to maintain calcium intake 1000 mg in young people and 1200–1400 mg/day in older women. Data on Geriatric depression (GDS) was collected using the validated long form at baseline and 12-months. The change in serum 25OHD was the primary outcome and GDS was one of the secondary outcomes. Adjustments were made for relevant covariates. Analysis of vitamin D effect was by dose low, medium and high compared to placebo or by quintiles. Serum 25OHD increased as a quadratic curve function to a mean of 46 ng/ml (115nmol/l) in white women and 49ng/ml (122.5nmol/L) in black women on the highest dose of 4800 IU. In older women mean GDS scores changed from 3.8 (SD±4.2) at baseline to 3.6 (SD±4.1) at 12 months in whites and from 3.0 (SD±3.7) to 3.02 (SD±4.2) in Blacks. (p = 0.790 in whites; p=0.958 in blacks). After 12-months there was no effect of dose on change in GDS score in women treated with different doses of vitamin D (p=0.507 in whites and p=0.340 in blacks). When both Caucasians and African Americans were divided into 3 dose groups, low (400-800 IU), medium (1600-3200 IU) and high (4000-4800 IU) doses, the change in score was 0.8 on low dose, −0.30 on medium dose and −0.31 on high dose compared to 0.11 on placebo (p=0.546). In summary, there was no improvement in GDS scores in Caucasians or African Americans on either increasing doses of vitamin D or quintiles of achieved response in serum 25OHD. The changes were small and not significant perhaps because of the relatively lower numbers of depressed women in the groups. Further studies should recruit larger numbers, 3 dose groups covering a serum25OHD range of 20–60ng/ml and more subjects with clinical depression in order to fully address the question of vitamin D effects on depression.
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欧洲老年人中25-羟基维生素D与禁食葡萄糖，禁食胰岛素，痴呆症和抑郁症的关联：塞内卡研究。
影响因子：
5
作者：
Brouwer-Brolsma EM;Feskens EJ;Steegenga WT;de Groot LC
通讯作者：
de Groot LC
影响因子：
6.6
作者：
Pan, An;Lu, Ling;Lin, Xu
通讯作者：
Lin, Xu
影响因子：
3.7
作者：
Dean AJ;Bellgrove MA;Hall T;Phan WM;Eyles DW;Kvaskoff D;McGrath JJ
通讯作者：
McGrath JJ
影响因子：
5
作者：
Brouwer-Brolsma EM;Dhonukshe-Rutten RA;van Wijngaarden JP;van der Zwaluw NL;Sohl E;In't Veld PH;van Dijk SC;Swart KM;Enneman AW;Ham AC;van Schoor NM;van der Velde N;Uitterlinden AG;Lips P;Feskens EJ;de Groot LC
通讯作者：
de Groot LC
DOI：
10.1186/1755-7682-3-29
发表时间：
2010-11-11
期刊：
International archives of medicine
影响因子：
--
作者：
Ganji V;Milone C;Cody MM;McCarty F;Wang YT
通讯作者：
Wang YT