Anti-Inflammatory Dembranoids from the Soft Coral Lobophytum crassum.
Anti-Inflammatory Dembranoids from the Soft Coral Lobophytum crassum.
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DOI：
10.3390/md15100327
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发表时间：
2017-10-23
期刊：
影响因子：
5.4
通讯作者：
Su JH
中科院分区：
文献类型：
--
作者：
Lai KH;You WJ;Lin CC;El-Shazly M;Liao ZJ;Su JH
胶膜型二萜类化合物是最常见的天然产物之一，来自Lobophyum属的软珊瑚。在从野生软珊瑚Lobophytom crassum中分离鉴定抗炎活性成分的过程中，分离得到了两个新的西贝内酯A(1)和B(2)，以及5个已知化合物(3-7)。这些天然产物的结构经核磁共振和质谱学确证。化合物1在所有的牛膜型二萜化合物中首次被鉴定为α-环氧内酯。对化合物1-5的体外抗炎作用进行评价。结果表明，化合物1-5不仅能减少内毒素激活的树突状细胞释放IL-12，而且还能减少NO的产生。我们的数据表明，分离得到的一系列胶膜型二萜类化合物具有有趣的结构特征和抗炎活性，可以进一步开发成治疗实体。
Cembrane-type diterpenoids are among the most frequently encountered natural products from the soft corals of the genus Lobophytum. In the course of our investigation to identify anti-inflammatory constituents from a wild-type soft coral Lobophytum crassum, two new cembranoids, lobophyolide A (1) and B (2), along with five known compounds (3–7), were isolated. The structures of these natural products were identified using NMR and MS spectroscopic analyses. Compound 1 was found to possess the first identified α-epoxylactone group among all cembrane-type diterpenoids. The in vitro anti-inflammatory effect of compounds 1–5 was evaluated. The results showed that compounds 1–5 not only reduced IL-12 release, but also attenuated NO production in LPS-activated dendritic cells. Our data indicated that the isolated series of cembrane-type diterpenoids demonstrated interesting structural features and anti-inflammatory activity which could be further developed into therapeutic entities.
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影响因子：
5.4
作者：
Bonnard I;Jhaumeer-Laulloo SB;Bontemps N;Banaigs B;Aknin M
通讯作者：
Aknin M
影响因子：
5.1
作者：
Edrada, RA;Proksch, P;van Ofwegen, LP
通讯作者：
van Ofwegen, LP
影响因子：
1.1
作者：
BOWDEN, BF;COLL, JC;STOKIE, GJ
通讯作者：
STOKIE, GJ
影响因子：
4
作者：
Cheng, Shi-Yie;Lin, Shih-Tseng;Duh, Chang-Yih
通讯作者：
Duh, Chang-Yih
影响因子：
1.8
作者：
Fattorusso, Ernesto;Romano, Adriana;Cerrano, Carlo
通讯作者：
Cerrano, Carlo