Neural regulation of bone marrow adipose tissue.

Neural regulation of bone marrow adipose tissue.
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DOI:
10.1016/j.beem.2021.101522
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发表时间:
2021-07
期刊:
Best practice & research. Clinical endocrinology & metabolism
影响因子:
--
通讯作者:
Scheller EL
Scheller EL
中科院分区:
其他
文献类型:
--
作者:
Zhang X;Hassan MG;Scheller EL

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骨髓脂肪组织(BMAT)是骨骼的重要细胞成分。了解它是如何被神经系统调节的,对于研究骨和骨髓相关疾病至关重要。BMAT受骨中的交感神经和感觉轴突支配,局部神经密度和功能的波动可能有助于其在各种骨骼部位的独特生理适应。BMAT直接响应肾上腺素能信号。此外,周围细胞的神经调节可能会改变BMAT特异性反应,为BMAT代谢的直接和间接神经调节提供了许多潜在途径。最后,BMAT和外周脂肪组织在中枢神经轴上共享相同的自主神经通路,BMAT的调节可能发生在神经和代谢疾病的不同临床环境中。这篇综述将突出什么是已知的和未知的BMAT的神经调节,并讨论在该领域的未来研究的机会。
Bone marrow adipose tissue (BMAT) is an important cellular component of the skeleton. Understanding how it is regulated by the nervous system is crucial to the study of bone and bone marrow related diseases. BMAT is innervated by sympathetic and sensory axons in bone and fluctuations in local nerve density and function may contribute to its distinct physiologic adaptations at various skeletal sites. BMAT is directly responsive to adrenergic signals. In addition, neural regulation of surrounding cells may modify BMAT-specific responses, providing many potential avenues for both direct and indirect neural regulation of BMAT metabolism. Lastly, BMAT and peripheral adipose tissues share the same autonomic pathways across the central neuraxis and regulation of BMAT may occur in diverse clinical settings of neurologic and metabolic disease. This review will highlight what is known and unknown about the neural regulation of BMAT and discuss opportunities for future research in the field.
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