Effects of cocaine on maternal behavior and neurochemistry.
Effects of cocaine on maternal behavior and neurochemistry.
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可卡因对孕产妇行为和神经化学的影响。
DOI：
10.2174/157015912799362760
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发表时间：
2012-03
影响因子：
5.3
通讯作者：
Febo M
中科院分区：
文献类型：
--
作者：
Nephew BC;Febo M
吸毒成瘾是一种慢性复发性疾病，尽管会造成负面的社会和健康后果，但仍涉及寻求和滥用药物。虽然在过去 30 年里，可卡因对儿童发育的潜在影响已得到广泛研究，但很少有研究人员关注可卡因对母亲行为的影响，包括照顾后代和母亲对陌生个体的攻击行为。对于人类来说，母亲吸食可卡因会导致儿童被忽视、虐待，并破坏母子关系。虽然有人认为母亲使用可卡因对儿童的发育影响最初被夸大了，但很明显，典型母亲行为的破坏（即产后抑郁症、焦虑症）不利于后代的身心健康。母亲吸食可卡因通常与心理障碍有关，包括抑郁和焦虑，据推测，母亲吸食可卡因对后代的许多负面影响是通过母亲行为的改变来介导的。这篇综述将总结动物和人类研究中可卡因和母亲行为的研究，讨论潜在的机制，并提出治疗可卡因影响的母亲行为的治疗策略，这可能会改善母亲和孩子的身体和行为健康。主要目标是促进利用动物和人类研究可卡因和母亲行为的研究人员之间未来的沟通、合作和协作。
Drug addiction is a chronic relapsing disorder that involves drug seeking and abuse despite the negative social and health consequences. While the potential effects of cocaine on child development have been extensively studied over the last 30 years, few researchers have focused on the effects of cocaine on maternal behavior, which includes offspring care and maternal aggression towards an unfamiliar individual. In humans, maternal cocaine use can lead to child neglect, abuse, and disrupt the mother-child bond. While it has been argued the developmental effects of maternal cocaine use on children were initially overstated, it is clear that disruptions of typical maternal behavior (i.e. postpartum depression, anxiety disorders) are detrimental to the physical and emotional health of offspring. Cocaine use in mothers is commonly associated with psychological disorders, including depression and anxiety, and it is postulated that many of the negative effects of maternal cocaine use on offspring are mediated through changes in maternal behavior. This review will summarize research on cocaine and maternal behavior in animal and human studies, discuss potential mechanisms, and suggest therapeutic strategies for treating cocaine-affected maternal behavior which may improve the physical and behavioral health of both mother and child. The primary objective is to stimulate future communication, cooperation, and collaboration between researchers who use animals and humans to study cocaine and maternal behavior.
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影响因子：
5
作者：
Chiu, J;Kalant, H;Lê, DA
通讯作者：
Lê, DA
DOI：
10.1111/j.1749-6632.1992.tb34382.x
发表时间：
1992-06-12
期刊：
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES-SERIES
影响因子：
--
作者：
FERRIS, CF;FOOTE, KB;INSEL, TR
通讯作者：
INSEL, TR
DOI：
10.1073/pnas.0807412105
发表时间：
2008-11-04
影响因子：
11.1
作者：
Bosch, Oliver J.;Neumann, Inga D.
通讯作者：
Neumann, Inga D.
影响因子：
4.7
作者：
Caffrey MK;Nephew BC;Febo M
通讯作者：
Febo M
影响因子：
11.3
作者：
Cleare, AJ;Bond, AJ
通讯作者：
Bond, AJ