Cognitive control links alcohol use, trait disinhibition, and reduced cognitive capacity: Evidence for medial prefrontal cortex dysregulation during reward-seeking behavior.
Cognitive control links alcohol use, trait disinhibition, and reduced cognitive capacity: Evidence for medial prefrontal cortex dysregulation during reward-seeking behavior.
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DOI：
10.1016/j.drugalcdep.2011.09.018
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发表时间：
2012-04-01
影响因子：
4.2
通讯作者：
Brown, Joshua W.
中科院分区：
文献类型：
--
作者：
Bogg, Tim;Fukunaga, Rena;Finn, Peter R.;Brown, Joshua W.
在认知控制反应-结果预测理论的指导下，本研究考察了寻求奖励的内侧前额叶皮层（mPFC）活动作为过量饮酒、特质去抑制和认知能力下降的常见神经功能标志物；所有这些都在以前的心理测量研究中显示出一致的共变模式（例如，）。在完成气球模拟风险任务的同时，用功能磁共振成像（fMRI）评估了一组18至23岁的酒精依赖患病率不同的大学生样本。研究人员还进行了一次典型的每周饮酒访谈、自我报告的特质去抑制和智商测量，以及复杂的跨期工作记忆任务。相关兴趣区域分析显示，在寻求奖励行为（连续的通货膨胀选择）中，更多的典型每周饮酒、更大的特征去抑制和更低的智商与mPFC活动的更大减少有关。结果还显示，在寻求奖励的结果（连续成功的通货膨胀结果）中，更多的典型每周饮酒、更大的特征去抑制和更低的智商与mPFC活动的更大增加有关。与工作记忆测量无显著关系。研究结果表明，在风险/奖励评估和绩效监测期间，mPFC的活动是过量饮酒、特质去抑制和低智商共同变化表达的共同神经功能特征。
Guided by the prediction of response-outcome theory of cognitive control, the present study examined reward-seeking medial prefrontal cortex (mPFC) activity as a common neuro-functional marker of excessive alcohol consumption, trait disinhibition, and reduced cognitive capacity; all of which have shown consistent patterns of covariation in previous psychometric research (e.g.,). A sample of 18-to-23-year-old university students with a heterogeneous prevalence of alcohol dependence was assessed with functional magnetic resonance imaging (fMRI) while completing a version of the Balloon Analogue Risk Task. A follow-back typical weekly alcohol consumption interview, self-report measures of trait disinhibition and IQ, and a complex span working memory task also were administered. Correlational region-of-interest analyses showed greater typical weekly alcohol consumption, greater trait disinhibition, and lower IQ were associated with greater reductions in mPFC activity during reward-seeking behaviors (successive inflation choices). The results also showed greater typical weekly alcohol consumption, greater trait disinhibition, and lower IQ were associated with greater increases in mPFC activity during reward-seeking outcomes (successive successful inflation outcomes). No significant relations with the measure of working memory were found. The findings suggest mPFC activity during risk/reward appraisal and performance monitoring is a common neuro-functional feature of co-varying expressions of excessive alcohol consumption, trait disinhibition, and lower IQ.
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额叶中的神经元编码多个决策变量的值。
影响因子：
3.2
作者：
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