Correlation between vitamin D levels in serum and the risk of dental caries in children: a systematic review and meta-analysis.
Correlation between vitamin D levels in serum and the risk of dental caries in children: a systematic review and meta-analysis.
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DOI：
10.1186/s12903-023-03422-z
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发表时间：
2023-10-19
期刊：
影响因子：
2.9
通讯作者：
Bai, Shizhu
中科院分区：
文献类型：
--
作者：
Li, Zizhan;Wei, Xiao;Shao, Zhongjun;Liu, Huan;Bai, Shizhu
维生素D在口腔健康中起着至关重要的作用，它的缺乏与口腔健康疾病的显著变化有关。目的探讨儿童龋病与25-羟基维生素D（25（OH）D）水平的关系。由两名研究者检索了4个电子数据库，包括PubMed、Embase、Web of Science和科克伦图书馆。龋齿结果以患病率或基于乳牙和恒牙/表面的腐烂、缺失和填充区域的指数呈现，而维生素D水平通过实验室测试确定。两名研究人员独立选择研究，收集信息，评估偏倚风险，并评估研究质量。任何分歧均通过讨论解决。共纳入13项研究，包括5项横断面研究，5项队列研究，3项病例对照研究，均具有较高的方法学质量。我们的荟萃分析显示，维生素D缺乏的儿童患龋齿的风险比维生素D水平正常的儿童高22%，相对风险（RR）为1.22，95%置信区间（CI）为1.18至1。25.根据3类研究进一步进行亚组分析，发现维生素D缺乏儿童患龋齿的风险高于维生素D水平正常组（队列研究：62%;横断面研究：19%;病例对照研究：5%）。此外，根据年龄，亚组分析也表明，维生素D缺乏儿童患龋齿的风险高于维生素D水平正常组（恒牙研究，28%;乳牙研究，68%;混合牙列研究8%）。已发现25（OH）D水平与儿童龋齿呈负相关，表明低维生素D水平可能被认为是这种牙科疾病的潜在危险因素。
Vitamin D plays a crucial role in oral health, and its deficiency is associated to significant changes in oral health diseases. We aimed to explore the relationship between levels of 25-hydroxyvitamin D (25(OH) D) and dental caries in children. Four electronic databases were searched by two investigators including PubMed, Embase, Web of Science, and Cochrane Library. Dental caries results were presented as either prevalence or based on the index of primary and permanent teeth/surfaces with decaying, missing, and filled areas, while vitamin D levels were determined through laboratory testing. Two researchers independently selected studies, collected information, assessed risk of bias, and evaluated the study quality. Any disagreements were resolved through discussion. A total of 13 studies were included, comprising 5 cross-sectional studies, 5 cohort studies, 3 case–control studies, all of which had high methodological quality. Our meta-analysis showed that children with vitamin D deficiency had a 22% higher risk of dental caries than those with normal vitamin D levels, with a relative risk (RR) of 1.22 and a 95% confidence interval (CI) of 1.18 to 1. 25. Further subgroup analysis according to the three types of studies showed that the risk of dental caries in children with vitamin D deficiency was higher than that in normal vitamin D level group (cohort studies: 62%; cross-sectional studies, 19%; and case–control studies, 5%). Additionally, according to age, subgroup analysis also showed that the risk of dental caries in children with vitamin D deficiency was higher than that in normal vitamin D level group (permanent teeth studies, 28%; deciduous teeth studies, 68%; and mixed dentition studies 8%). Levels of 25 (OH) D have been found negatively associated with dental caries in children, indicating that low vitamin D levels may be considered a potential risk factor to this dental disease.
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影响因子：
5.9
作者：
Carvalho Silva C;Gavinha S;Manso MC;Rodrigues R;Martins S;Guimarães JT;Santos AC;Melo P
通讯作者：
Melo P
影响因子：
1.2
作者：
Al-Jubori, Sawsan Hameed;AL-Murad, Maha A.;Al-Mashhadane, Faehaa Azher
通讯作者：
Al-Mashhadane, Faehaa Azher
影响因子：
3.1
作者：
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通讯作者：
Gombart AF
影响因子：
1.2
作者：
D'Ortenzio, Lori;Kahlon, Bonnie;Brickley, Megan
通讯作者：
Brickley, Megan
DOI：
10.1016/j.ecl.2010.02.010
发表时间：
2010-06
影响因子：
4.5
作者：
Hewison, Martin
通讯作者：
Hewison, Martin