Combination of nanolamellae and PDA coating on promoting the long-term adhesion, proliferation, and differentiation of osteoblasts
Combination of nanolamellae and PDA coating on promoting the long-term adhesion, proliferation, and differentiation of osteoblasts
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纳米片层和PDA涂层的结合促进成骨细胞的长期粘附、增殖和分化
DOI：
10.1016/j.polymer.2020.122462
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发表时间：
2020-05
期刊：
影响因子：
4.6
通讯作者：
Li Zhong-Ming
中科院分区：
文献类型：
--
作者：
Zhao Baisong;Zheng Zi-Li;Liu Wei;Yin Hua-Mo;Lan Ri-Tong;Xu Ling;Xu Jia-Zhuang;Song Xingrong;Li Zhong-Ming
通过碱蚀刻和聚多巴胺（PDA）涂层将纳米形貌和化学线索共同引入到聚（L-乳酸）（PLLA）表面。表面图案由致密的PLLA片层组成，PDA涂层没有改变表面形貌特征。纳米形貌图案和 PDA 涂层均在细胞培养基中表现出两周的长期稳定性。体外评估表明，即使培养时间为两周，纳米形貌和 PDA 涂层对成骨细胞的细胞粘附、增殖和分化也具有协同作用。这种持续的作用归因于 wnt/β-连环蛋白途径的激活。这些结果为骨修复移植物的应用带来了广阔的前景。
Nanotopographical and chemical cues were collectively introduced onto the poly(L-lactic acid) (PLLA) surface via alkali etching and polydopamine (PDA) coating. The surface pattern was made of dense-packed PLLA lamellae, and the PDA coating did not change the feature of surface topography. Both nanotopographical pattern and PDA coating showed long-term stability in cell culture medium for two weeks. In vitro evaluations displayed that there was a synergy between nanotopography and PDA coating on cell adhesion, proliferation, and differentiation of osteoblasts, even for a culture period of two weeks. This sustained effect was attributed to the activation of the wnt/β-catenin pathway. These results hold a promising prospect for the application of bone repair grafts.
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影响因子：
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