NADH Dehydrogenase Subunit-2 237 Leu/Met Polymorphism Influences the Association of Coffee Consumption with Serum Chloride Levels in Male Japanese Health Checkup Examinees: An Exploratory Cross-Sectional Analysis.
NADH Dehydrogenase Subunit-2 237 Leu/Met Polymorphism Influences the Association of Coffee Consumption with Serum Chloride Levels in Male Japanese Health Checkup Examinees: An Exploratory Cross-Sectional Analysis.
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DOI：
10.3390/nu10101344
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发表时间：
2018-09-20
期刊：
影响因子：
5.9
通讯作者：
Takashima Y
中科院分区：
文献类型：
--
作者：
Kokaze A;Ishikawa M;Matsunaga N;Karita K;Yoshida M;Ochiai H;Shirasawa T;Yoshimoto T;Minoura A;Oikawa K;Satoh M;Hoshino H;Takashima Y
背景：烟酰胺腺嘌呤二核苷酸(NADH)脱氢酶亚单位-2237亮氨酸/蛋氨酸(ND2-237Leu/Met)基因多态性已被证明可以改变咖啡消费与高血压、血脂异常和糖耐量异常风险的关联，而且低血氯水平已被证明与各种原因和心血管疾病的死亡率有关。因此，本研究的目的是探讨ND2-237Leu/Met基因多态性是否影响男性健康体检者咖啡摄入量与血清氯水平的关系。方法：从来医院进行定期体检的个体中，选择402名男性(平均年龄±标准差，53.9±7.8岁)纳入研究。在ND2-237Leu/Met基因分型后，我们进行了一项探索性横断面研究，以考察ND2-237Leu/Met基因多态和咖啡摄入量与血清电解质水平的联合关系。结果：在调整了年龄、体重指数、习惯性吸烟、饮酒、绿茶消费和降压药物后，饮用咖啡显著增加了ND2-237Leu基因型男性的血清氯水平(趋势=0.001)。在这些调整后，低水平血清氯的优势比(OR)，定义为100mEq/L，被发现依赖于咖啡消费量(趋势=0.001)。此外，与每天喝一杯咖啡相比，具有ND2-237Leu基因的男性每天饮用≥4与1杯咖啡相比，低水平血清氯的OR显著降低(OR=0.096，95%可信区间=0.010-0.934；p=0.044)。然而，无论是血清氯水平还是低血清氯水平的风险似乎都不依赖于咖啡的摄入量。结论：在日本中年男性中，ND2-237Leu/Met基因多态性改变了咖啡摄入量与血清氯水平的关系。
Background: Nicotinamide adenine dinucleotide (NADH) dehydrogenase subunit-2 237 leucine/methionine (ND2-237 Leu/Met) polymorphism has been shown to modify the association of coffee consumption with the risk of hypertension, dyslipidemia, and abnormal glucose tolerance, and low serum chloride levels have been shown to be associated with all-cause and cardiovascular disease mortality. Therefore, the purpose of the present study was to investigate whether ND2-237 Leu/Met polymorphism influences the association of coffee consumption with serum chloride levels in male Japanese health checkup examinees. Methods: From among individuals visiting the hospital for a regular medical checkup, 402 men (mean age ± standard deviation, 53.9 ± 7.8 years) were selected for inclusion in the study. After ND2-237 Leu/Met genotyping, we conducted an exploratory cross-sectional study to examine the combined association of ND2-237 Leu/Met polymorphism and coffee consumption with serum electrolyte levels. Results: After adjusting for age, body mass index, habitual smoking, alcohol consumption, green tea consumption, and antihypertensive medication, coffee consumption significantly increased serum chloride levels (p for trend = 0.001) in men with the ND2-237Leu genotype. After these adjustments, the odds ratios (ORs) for low levels of serum chloride, defined as <100 mEq/L, were found to be dependent on coffee consumption (p for trend = 0.001). In addition, the OR for low levels of serum chloride was significantly lower in men with the ND2-237Leu genotype who consumed ≥4 compared with <1 cup of coffee per day (OR = 0.096, 95% confidence interval = 0.010–0.934; p = 0.044). However, neither serum chloride levels nor risk of low levels of serum chloride appeared to be dependent on coffee consumption. Conclusions: The results suggest that ND2-237 Leu/Met polymorphism modifies the association of coffee consumption with serum chloride levels in middle-aged Japanese men.
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影响因子：
3.1
作者：
Kokaze A;Yoshida M;Ishikawa M;Matsunaga N;Karita K;Ochiai H;Shirasawa T;Nanri H;Mitsui K;Hoshimo H;Takashima Y
通讯作者：
Takashima Y
影响因子：
3.1
作者：
Kokaze A;Ishikawa M;Matsunaga N;Karita K;Yoshida M;Ohtsu T;Ochiai H;Shirasawa T;Nanri H;Saga N;Ohtsu I;Hoshino H;Takashima Y
通讯作者：
Takashima Y
影响因子：
6.1
作者：
Rodriguez-Artalejo, Fernando;Lopez-Garcia, Esther
通讯作者：
Lopez-Garcia, Esther
影响因子：
4.4
作者：
Ohkubo, R;Nakagawa, M;Osame, M
通讯作者：
Osame, M
影响因子：
5.3
作者：
Kokaze, A;Ishikawa, M;Takashima, Y
通讯作者：
Takashima, Y