Gender-associated factors for frailty and their impact on hospitalization and mortality among community-dwelling older adults: a cross-sectional population-based study.
Gender-associated factors for frailty and their impact on hospitalization and mortality among community-dwelling older adults: a cross-sectional population-based study.
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作者：
Zhang Q;Guo H;Gu H;Zhao X
与衰老相关的虚弱会增加跌倒、残疾和死亡的风险。我们调查了与衰弱有关的性别因素。从2007-2010年国家健康与营养检查调查（NHANES）数据库中检索3079名老年受试者的数据。在排除了1,126名缺乏虚弱、病史和生存数据的受试者后，对1,953名患者的数据进行了分析。主要终点是虚弱患病率、死亡率和死亡原因。男性虚弱患病率为5.4%，女性为8.8%。男性老年虚弱的显著危险因素为丧偶/离婚/分居、每日总热量摄入低、缺乏运动、睡眠不足9小时、吸烟和住院史；女性肥胖、缺乏运动、睡眠时间<6小时、有糖尿病和心脏病家族史、住院史。体弱受试者的死亡率（男性22.5%，女性8.5%）高于体弱前受试者（男性8.7%，女性6.4%）和非体弱受试者（男性5.4%，女性2.5%）。男性的主要死亡原因是心脏病（41%）和慢性下呼吸道疾病（23.0%），女性的主要死亡原因是肾炎/肾病（32.3%）和慢性下呼吸道疾病（17.6%）。与虚弱相关的因素因性别而异，女性的虚弱患病率较高，而男性的死亡率较高。本研究确定的与性别有关的脆弱因素可能有助于评估脆弱和指导制定预防公共卫生措施。老年人虚弱的常见预测因素，包括以前更频繁的住院治疗、缺乏身体活动和某些与虚弱有关的性别因素，与其他NHANES研究的结果一致，在这些研究中，自我报告的较高水平的疾病和久坐行为与虚弱直接相关。
Frailty associated with aging increases the risk of falls, disability, and death. We investigated gender-associated factors for frailty. Data of 3,079 geriatric subjects were retrieved from the National Health and Nutrition Examination Survey (NHANES) 2007–2010 database. After excluding 1,126 subjects with missing data on frailty, medical history and survival, data of 1,953 patients were analyzed. Main endpoints were frailty prevalence, mortality rates and causes of death. Frailty prevalence was 5.4% in males, 8.8% in females. Significant risk factors for geriatric frailty in males were being widowed/divorced/separated, low daily total calorie intake, physical inactivity, sleeping >9 h, smoking and hospitalization history; and in females were obesity, physical inactivity, sleeping <6 h, family history of diabetes and heart attack, and hospitalization history. Frail subjects had higher mortality rates (22.5% male; 8.5% female) than pre-frail (8.7% male; 6.4% female) and non-frail (5.4% male; 2.5% female). Main causes of death were heart diseases (41%) and chronic lower respiratory diseases (23.0%) in males and nephritis/nephrosis (32.3%) and chronic lower respiratory diseases (17.6%) in females. Factors associated with frailty differ by gender, with higher frailty prevalence in females and higher mortality in males. Gender-associated factors for frailty identified in this study may be useful in evaluating frailty and guiding development of public health measures for prevention. Common predictive factors for frailty among older adults of both genders, including more frequent previous hospitalizations, physical inactivity, and certain gender-associated factors for frailty, are consistent with results of other NHANES studies in which self-reported higher levels of illness and sedentary behavior were directly associated with frailty.
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影响因子：
3.9
作者：
Eichholzer, Monika;Richard, Aline;Rohrmann, Sabine
通讯作者：
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影响因子：
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作者：
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DOI：
10.1007/s12603-012-0084-2
发表时间：
2012-07
期刊：
The journal of nutrition, health & aging
影响因子：
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通讯作者：
Miller DK
DOI：
10.1111/j.1532-5415.2010.02764.x
发表时间：
2010-04-01
影响因子：
6.3
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