Gestational Exposure to Phthalates and Social Responsiveness Scores in Children Using Quantile Regression: The EARLI and HOME Studies.
Gestational Exposure to Phthalates and Social Responsiveness Scores in Children Using Quantile Regression: The EARLI and HOME Studies.
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DOI：
10.3390/ijerph18031254
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发表时间：
2021-01-30
影响因子：
--
通讯作者：
Braun JM
中科院分区：
文献类型：
--
作者：
Patti MA;Newschaffer C;Eliot M;Hamra GB;Chen A;Croen LA;Fallin MD;Hertz-Picciotto I;Kalloo G;Khoury JC;Lanphear BP;Lyall K;Yolton K;Braun JM
Linear regression is often used to estimate associations between chemical exposures and neurodevelopment at the mean of the outcome. However, the potential effect of chemicals may be greater among individuals at the ‘tails’ of outcome distributions. Here, we investigated distributional effects on the associations between gestational phthalate exposure and child Autism Spectrum Disorder (ASD)-related behaviors using quantile regression. We harmonized data from the Early Autism Risk Longitudinal Investigation (EARLI) (n = 140) Study, an enriched-risk cohort of mothers who had a child with ASD, and the Health Outcomes and Measures of the Environment (HOME) Study (n = 276), a general population cohort. We measured concentrations of 9 phthalate metabolites in urine samples collected twice during pregnancy. Caregivers reported children’s ASD-related behaviors using the Social Responsiveness Scale (SRS) at age 3–8 years; higher scores indicate more ASD-related behaviors. In EARLI, associations between phthalate concentrations and SRS scores were predominately inverse or null across SRS score quantiles. In HOME, positive associations of mono-n-butyl phthalate, monobenzyl phthalate, mono-isobutyl phthalate, and di-2-ethylhexyl phthalate concentrations with SRS scores increased in strength from the median to 95th percentile of SRS scores. These results suggest associations between phthalate concentrations and SRS scores may be stronger in individuals with higher SRS scores.
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影响因子：
10.4
作者：
Braun JM;Kalkbrenner AE;Just AC;Yolton K;Calafat AM;Sjödin A;Hauser R;Webster GM;Chen A;Lanphear BP
通讯作者：
Lanphear BP
DOI：
10.1038/nrendo.2016.186
发表时间：
2017-03
期刊：
Nature reviews. Endocrinology
影响因子：
--
作者：
Braun JM
通讯作者：
Braun JM
影响因子：
10.6
作者：
Constantino, JN;Todd, RD
通讯作者：
Todd, RD
DOI：
10.1111/j.1469-7610.2004.00266.x
发表时间：
2004-05-01
影响因子：
7.6
作者：
Constantino, JN;Gruber, CP;Przybeck, T
通讯作者：
Przybeck, T
影响因子：
3.6
作者：
Braun JM;Sathyanarayana S;Hauser R
通讯作者：
Hauser R