The modulation of lifespan by perceptual systems.
The modulation of lifespan by perceptual systems.
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DOI：
10.1111/j.1749-6632.2009.04926.x
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发表时间：
2009-07
影响因子：
5.2
通讯作者：
Pletcher SD
中科院分区：
文献类型：
--
作者：
Pletcher SD
仅仅是对食物可获得性的感知是否会逆转饮食限制的有益影响，而饮食限制在许多物种中有力地增加了寿命并减少了与衰老相关的疾病？我们从之前对果蝇的研究中注意到，饮食限制的效果是快速作用的，完全可逆的，并且在很大程度上与食物的能量含量无关。事实上，果蝇似乎能够“感知”食物的某些特征，而不依赖于它们吃食物的倾向。我们很快意识到，果蝇的嗅觉系统，以及其众所周知的结构和相关的一套遗传工具，是检验我们假设的理想模型。随后的工作导致识别出特定的气味和感觉神经元群体，这些神经元对寿命、肥胖和新陈代谢有强烈的影响。
Could the mere perception of food availability reverse the beneficial effects of diet restriction, which robustly increases lifespan and reduces aging-related disease in many species? We had noted from previous work in Drosophila that the effects of dietary restriction were fast acting, completely reversible, and largely independent of the energetic content of the food. Indeed, some characteristic of the diet seemed to be “sensed” by the flies independent of their tendency to eat it. We quickly realized that the Drosophila olfactory system, with its well-understood architecture and associated set of genetic tools, was the ideal model to test our hypothesis. Subsequent work resulted in the identification of particular odorants and populations of sensory neurons with potent effects on lifespan, obesity, and metabolism.
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卡路里不能通过果蝇饮食限制来解释寿命的延长。
影响因子：
9.8
作者：
Mair, William;Piper, Matthew D W;Partridge, Linda
通讯作者：
Partridge, Linda
影响因子：
8.2
作者：
Apfelbach, R;Blanchard, CD;McGregor, IS
通讯作者：
McGregor, IS
影响因子：
2.1
作者：
CHIPPINDALE, AK;LEROI, AM;ROSE, MR
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ROSE, MR
影响因子：
30.8
作者：
Anholt, RRH;Dilda, CL;Mackay, TFC
通讯作者：
Mackay, TFC
影响因子：
25
作者：
Neuhaus, EM;Gisselmann, G;Hatt, H
通讯作者：
Hatt, H