The role of the cerebellum in internet gaming disorder-A systematic review.
The role of the cerebellum in internet gaming disorder-A systematic review.
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作者：
最近的研究越来越强调小脑参与药物渴望和成瘾。然而，它的确切作用，即，小脑是否是成瘾行为背后的大脑网络的关键组成部分，或者说它是一个促进者或调解者，目前还不清楚。关于新发现的网络游戏障碍（IGD）的研究结果表明，小脑连接和功能的变化与行为/非物质成瘾有关。在这里，我们系统地回顾了IGD和小脑参与PRISMA指南的文献。共有13项神经影像学研究符合纳入标准。研究使用了广泛的诊断工具和由此产生的截止标准，因此难以比较结果。IGD患者小脑-小脑连接改变的结果是混合的，大多数研究报告功能连接改变或增加。此外，还报告了小脑灰质体积减少。研究进一步表明，小脑中的差异激活模式可以区分健康受试者和IGD受试者，甚至可以预测治疗结果。鉴于小脑和大脑区域之间的强连接性，小脑可能作为参与渴望和成瘾的区域之间的中介，从而影响IGD的症状。结果表明小脑叶的差异参与，强调在未来的研究中需要高分辨率的小脑parcellation。然而，本综述中所包括的研究样本量较小，并且主要包括男性参与者。因此，结果可能具有有限的普遍性，但强调了小脑在IGD中的重要作用，需要进一步研究。
Recent studies increasingly highlight involvement of the cerebellum in drug craving and addiction. However, its exact role, i.e., whether the cerebellum is a critical component of a brain network underlying addictive behavior, or whether it rather is a facilitator or mediator, is still unclear. Findings concerning the newly recognized internet gaming disorder (IGD) suggest that changes in cerebellar connectivity and functioning are associated with behavioral/non-substance addiction. Here, we systematically review the literature on IGD and cerebellar involvement following the PRISMA guidelines. A total of thirteen neuroimaging studies met the inclusion criteria. Studies utilized a broad range of diagnostic instruments and resulting cut-off criteria, rendering it difficult to compare findings. Results on altered cerebro-cerebellar connectivity in patients with IGD are mixed, most studies report altered or increased functional connectivity. Moreover, decreased cerebellar gray matter volume is reported. Studies have further indicated that differential activation patterns in the cerebellum may enable discrimination between healthy subjects and subjects with IGD, even allowing for prediction of treatment outcomes. Given the strong connectivity between cerebellum and cerebral regions, the cerebellum may act as an intermediary between regions involved in craving and addiction and consequently affect symptoms of IGD. Results suggest differential involvement of the cerebellar lobes, emphasizing a need for high-resolution parcellation of the cerebellum in future studies. However, the studies included in the present review have small sample sizes and include mostly male participants. Thus, results may have limited generalizability, yet highlight a crucial role of the cerebellum in IGD that needs further investigation.
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影响因子：
3.4
作者：
Moulton EA;Elman I;Becerra LR;Goldstein RZ;Borsook D
通讯作者：
Borsook D
DOI：
10.1016/j.pnpbp.2018.04.009
发表时间：
2019-01-10
影响因子：
5.6
作者：
Dong, Guangheng;Wang, Ziliang;Potenza, Marc N.
通讯作者：
Potenza, Marc N.
影响因子：
3.4
作者：
Han, Doug Hyun;Kim, Sun Mi;Anderson, Jeffrey S.
通讯作者：
Anderson, Jeffrey S.
网络游戏成瘾者静息态大脑活动区域同质性的变化
DOI：
10.1186/1744-9081-8-41
发表时间：
2012-08-18
期刊：
Behavioral and brain functions : BBF
影响因子：
--
作者：
Dong G;Huang J;Du X
通讯作者：
Du X
影响因子：
4.4
作者：
Han JW;Han DH;Bolo N;Kim B;Kim BN;Renshaw PF
通讯作者：
Renshaw PF