Heat shock increases hydrogen peroxide release from circulating hemocytes of the snail Biomphalaria glabrata.
Heat shock increases hydrogen peroxide release from circulating hemocytes of the snail Biomphalaria glabrata.
复制标题
DOI：
10.1016/j.fsi.2020.07.029
复制
发表时间：
2020-10
影响因子：
4.7
通讯作者：
Blouin MS
中科院分区：
文献类型：
--
作者：
Allan ERO;Blouin MS
平病性淡水螺是由寄生蠕虫引起的寄生虫病的重要中间宿主，最显著的是血吸虫病。有许多关于蜗牛的报道，特别是光滑双脐螺，在暴露于热应激后对嗜热小体的防御能力受损。在气候变化的背景下，环境对血吸虫传播蜗牛防御能力的改变可能会对人类疾病风险产生负面影响。在这里，过氧化氢，在许多软体动物的主要抗菌效应的生产热休克的影响，进行了检查。目前的研究结果表明，热休克增加NADPH氧化酶2的mRNA水平和过氧化氢产生的蜗牛血细胞，这两种表型可以逆转的HSP-90抑制剂。这些发现表明，蜗牛防御系统改变热休克在分子水平上的B。glabrata，蜗牛对许多病原体的免疫力可能会被与全球气候变化相关的温度快速变化所改变。
Planorbid freshwater snails are important intermediate hosts for parasitic diseases caused by parasitic worms, most notably schistosomiasis. There are numerous reports of snails, specifically Biomphalaria glabrata, having compromised defences against schistosomes after being exposed to thermal stress. Environmental modifications to the defenses of schistosome transmitting snails could have negative ramifications for human disease risk in the context of climate change. Here the effects of heat shock on the production of hydrogen peroxide, a primary anti-microbial effector in many molluscs, were examined. The present findings show that heat shock increases NADPH oxidase 2 mRNA levels and hydrogen peroxide produced by snail hemocytes, and that both of these phenotypes could be reversed by an HSP-90 inhibitor. These findings indicate that snail defense systems are altered by heat shock at a molecular level in B. glabrata, and that snail immunity to many pathogens may be altered by the rapid variations in temperature that are associated with global climate change.
登录
查看更多内容
影响因子：
1.3
作者：
Basso, W;Venturini, L;Dubey, JP
通讯作者：
Dubey, JP
影响因子：
4.7
作者：
Allan ERO;Blouin MS
通讯作者：
Blouin MS
影响因子：
1.3
作者：
Bender, RC;Broderick, EJ;Bayne, CJ
通讯作者：
Bayne, CJ
影响因子：
4
作者：
Humphries, JE;Yoshino, TP
通讯作者：
Yoshino, TP
影响因子：
4
作者：
Larson MK;Bender RC;Bayne CJ
通讯作者：
Bayne CJ