Global expansion of Mycobacterium tuberculosis lineage 4 shaped by colonial migration and local adaptation.
Global expansion of Mycobacterium tuberculosis lineage 4 shaped by colonial migration and local adaptation.
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结核分枝杆菌谱系4的全球扩展，由殖民地迁移和局部适应。
DOI：
10.1126/sciadv.aat5869
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发表时间：
2018-10
期刊：
影响因子：
13.6
通讯作者：
Eldholm V
中科院分区：
文献类型：
--
作者：
Brynildsrud OB;Pepperell CS;Suffys P;Grandjean L;Monteserin J;Debech N;Bohlin J;Alfsnes K;Pettersson JO;Kirkeleite I;Fandinho F;da Silva MA;Perdigao J;Portugal I;Viveiros M;Clark T;Caws M;Dunstan S;Thai PVK;Lopez B;Ritacco V;Kitchen A;Brown TS;van Soolingen D;O'Neill MB;Holt KE;Feil EJ;Mathema B;Balloux F;Eldholm V
耐多药谱系4结核病的兴起背后是反复出现，而不是国际传播。基于对1669株结核分枝杆菌谱系4（L4）基因组的群体基因组学和地理学分析，我们发现L4的扩散完全受欧洲以外的历史迁移的支配。我们证明了欧洲殖民扩张到非洲和美洲和L4结核病（TB）的传播之间的密切的时间关系。值得注意的是，在抗生素时代，赋予抗菌素耐药性的突变绝大多数出现在当地（在国家一级），耐药性的跨境传播很少。发现后一个发现反映了这些突变相对较新的出现，因为对于在可比时间尺度上出现的易感变体，观察到类似程度的局部限制。抗药性结核病的国际传播受到限制，这表明各国的遏制努力可能会取得成功。
Repeated emergence, not international dissemination, is behind the rise of multidrug-resistant lineage 4 tuberculosis. On the basis of population genomic and phylogeographic analyses of 1669 Mycobacterium tuberculosis lineage 4 (L4) genomes, we find that dispersal of L4 has been completely dominated by historical migrations out of Europe. We demonstrate an intimate temporal relationship between European colonial expansion into Africa and the Americas and the spread of L4 tuberculosis (TB). Markedly, in the age of antibiotics, mutations conferring antimicrobial resistance overwhelmingly emerged locally (at the level of nations), with minimal cross-border transmission of resistance. The latter finding was found to reflect the relatively recent emergence of these mutations, as a similar degree of local restriction was observed for susceptible variants emerging on comparable time scales. The restricted international transmission of drug-resistant TB suggests that containment efforts at the level of individual countries could be successful.
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影响因子：
3.7
作者：
Donoghue, Helen D.
通讯作者：
Donoghue, Helen D.
影响因子：
64.8
作者：
Bos KI;Harkins KM;Herbig A;Coscolla M;Weber N;Comas I;Forrest SA;Bryant JM;Harris SR;Schuenemann VJ;Campbell TJ;Majander K;Wilbur AK;Guichon RA;Wolfe Steadman DL;Cook DC;Niemann S;Behr MA;Zumarraga M;Bastida R;Huson D;Nieselt K;Young D;Parkhill J;Buikstra JE;Gagneux S;Stone AC;Krause J
通讯作者：
Krause J
影响因子：
3.2
作者：
David, Susana;Duarte, Elsa L.;de Sousa, Jose Germano
通讯作者：
de Sousa, Jose Germano
DOI：
10.1073/pnas.1611283113
发表时间：
2016-11-29
影响因子：
11.1
作者：
Eldholm, Vegard;Pettersson, John H. -O.;Balloux, Francois
通讯作者：
Balloux, Francois
影响因子：
16.6
作者：
Eldholm, Vegard;Monteserin, Johana;Rieux, Adrien;Lopez, Beatriz;Sobkowiak, Benjamin;Ritacco, Viviana;Balloux, Francois
通讯作者：
Balloux, Francois