Gene-environment studies and borderline personality disorder: a review.

Gene-environment studies and borderline personality disorder: a review.
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DOI:
10.1007/s11920-012-0336-1
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发表时间:
2013-01
影响因子:
6.7
通讯作者:
Boomsma, Dorret I.
Boomsma, Dorret I.
中科院分区:
医学2区
文献类型:
--
作者:
Carpenter, Ryan W.;Tomko, Rachel L.;Trull, Timothy J.;Boomsma, Dorret I.

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We review recent gene-environment studies relevant to borderline personality disorder, including those focusing on impulsivity, emotion sensitivity, suicidal behavior, aggression and anger, and the borderline personality phenotype itself. Almost all the studies reviewed suffered from a number of methodological and statistical problems, limiting the conclusions that currently can be drawn. The best evidence to date supports a gene-environment correlation (rGE) model for borderline personality traits and a range of adverse life events, indicating that those at risk for BPD are also at increased risk for exposure to environments that may trigger BPD. We provide suggestions regarding future research on GxE interaction and rGE effects in borderline personality.
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