Plasma fatty acid composition and incident heart failure in middle-aged adults: the Atherosclerosis Risk in Communities (ARIC) Study.
Plasma fatty acid composition and incident heart failure in middle-aged adults: the Atherosclerosis Risk in Communities (ARIC) Study.
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DOI：
10.1016/j.ahj.2008.06.017
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发表时间：
2008-11
影响因子：
4.8
通讯作者：
Folsom, Aaron R.
中科院分区：
文献类型：
--
作者：
Yamagishi, Kazumasa;Nettleton, Jennifer A.;Folsom, Aaron R.
一些先前的前瞻性研究表明，膳食中ω-3多不饱和脂肪酸的摄入与心力衰竭（HF）的风险降低有关，但尚无研究探讨血浆脂肪酸与HF之间的关系。我们纳入了3,592名白色参与者，他们来自明尼阿波利斯现场中心的动脉粥样硬化风险社区（ARIC）研究，基线年龄为45-64岁（1987-89），最初无冠心病、中风和HF，并测量了胆固醇酯和磷脂血浆脂肪酸。参与者随访至2003年，HF事件定义为出院或死亡，包括HF ICD代码。在14.3年的随访中，我们确定了197例HF病例（男性110例，女性87例）。在调整年龄和其他混杂因素后，男性和女性的高饱和脂肪酸，尤其是肉豆蔻酸（14：0）与HF事件呈正相关。高花生四烯酸（20：3，ω-6）和长链ω-3多不饱和脂肪酸，特别是二十二碳六烯酸（22：6，ω-3），与女性HF呈负相关，但与男性无关。血浆α-亚麻酸和二十碳五烯酸均与HF事件无关。在男性和女性中，较高水平的饱和脂肪酸可能会增加HF的风险。在女性中，花生四烯酸和长链ω-3多不饱和脂肪酸可降低HF的风险。(211字数/ 250个限制）
Some previous prospective studies showed that dietary intake of ω-3 polyunsaturated fatty acids was associated with lower risk of heart failure (HF), but no study has examined the association between plasma fatty acids and HF. We included 3,592 white participants from the Minneapolis field center of the Atherosclerosis Risk in Communities (ARIC) Study, aged 45-64 at baseline (1987-89), initially free of coronary heart disease, stroke and HF, and who had cholesterol ester and phospholipid plasma fatty acids measured. Participants were followed through 2003, and incident HF was defined by a hospital discharge or death including a HF ICD code. During the 14.3-year follow-up, we identified 197 cases of HF (110 for men and 87 for women). After adjustment for age and other confounders, higher saturated fatty acids, especially myristic (14:0) acid, were associated positively with incident HF in both men and women. Higher arachidonic (20:3,ω-6) and long-chain ω-3 polyunsaturated fatty acids, especially docosahexaenoic (22:6,ω-3), were associated inversely with HF in women, but not in men. Neither plasma α-linolenic nor eicosapentaenoic acid was associated with incident HF. In both men and women, greater levels of saturated fatty acids may increase risk of HF. In women, arachidonic acid and long-chain ω-3 polyunsaturated fatty acids may decrease risk of HF. (211 words/ 250 limits)
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